To investigate the role of ATM protein in protecting against neurodegeneration

该项目的总体目标是使用大鼠模型来研究共济失调-毛细血管扩张症(A-T)患者的神经变性。共济失调-毛细血管扩张症是一种复杂的多系统疾病，以进行性神经功能障碍、可变免疫缺陷和癌症易感性为特征。大鼠模型重述了患者的神经退行性变，因此该项目将为了解缺陷的性质以及治疗该疾病的方法提供重要的见解。

The overall aim of the project is to employ a rat model to investigate neurodegeneration in patients with ataxia-telangiectasia (A-T). Ataxia-telangiectasia is a complex multisystem disorder characterised by progressive neurological impairment, variable immunodeficiency and cancer predisposition. The rat model recapitulates the neurodegeneration in patients and thus this project will provide important insight into the nature of the defect as well as approaches for the treatment of the disorder.