Bacterial outer membrane vesicles as immunomodulatory agents in Helicobacter pylori infection

慢性胃炎是幽门螺杆菌感染的标志，是消化性溃疡疾病和癌症的前兆。像许多其他细菌一样，幽门螺旋杆菌从表面脱落球形气泡。这些水泡在体外与胃细胞结合，并在幽门螺杆菌感染受试者的胃活检中发现。这项工作的目的是研究幽门螺旋杆菌进入和传播宿主细胞的机制，以及这可能如何导致炎症。

Chronic inflammation of the stomach is a hallmark of Helicobacter pylori infection, and is a precursor to peptic ulcer disease and cancer. Like many other bacteria, H. pylori sheds spherical blebs from its surface. These blebs bind to stomach cells in vitro and have been found in stomach biopsies of H. pylori-infected subjects. The aims of the work are to investigate the mechanisms whereby H. pylori blebs enter and disseminate within host cells, and how this may contribute to inflammation.