Chromatographic analysis equipment for a synthetic organic chemistry laboratory

这项提案是针对合成有机化学实验室所需的关键设备提出的。硫存在于大量生物和药理上的重要分子中，包括抗生素、抗肿瘤、抗溃疡、抗炎、抗糖尿病、抗哮喘、抗病毒、抗精神病、强心、抗过敏和抗偏头痛药物，以及治疗前列腺肥大和男性勃起功能障碍的药物。尽管所有这些值得注意的临床化合物中都存在硫，但将硫安装到分子中的方法远远落后于安装氧气或氮气的技术。我们的研究目标是开发通用的、广泛范围的方法来构建含硫分子。为了开展这项工作，我们需要两台设备：一台气相色谱/质谱仪(GC/MS)和一台高效液相色谱仪(HPLC)。这项研究的长期成功将严重影响药物化学和药物发现领域，导致新的、更便宜和更有效的药物。

This proposal is for critical equipment needed in a synthetic organic chemistry laboratory. Sulfur is present in a vast array of biologically and pharmacologically important molecules, including antibiotics, anti-tumor, anti-ulcerative, anti-inflammatory, anti-diabetic, anti-asthma, anti-viral, anti-psychotic, cardiotonic, anti-allergic and anti-migraine agents, as well as treatments for enlargement of the prostate gland and male erectile dysfunction. Despite the presence of sulfur in all of these noteworthy clinical compounds, methods for installation of sulfur into molecules are far less developed than techniques for installing oxygen or nitrogen. The goal of our research is to develop general, broad scope methods for the construction of sulfur-containing molecules. In order to carry out this work we require two pieces of equipment: a gas chromatograph/mass spectrometer (GC/MS) and a high performance liquid chromatograph (HPLC). The long term success of this research would heavily impact the worlds of medicinal chemistry and drug discovery, leading to new, cheaper and more effective medicines.