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Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways

Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways
捕获选择性调节 PAR2 信号通路的新药物
批准号:
nhmrc : 1047759
负责人:
Prof David Fairlie
金额:
$31.28万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

项目摘要

项目成果

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中文摘要
翻译
感染和组织损伤会引发急性炎症反应,这种反应有时会不加控制地持续下去,导致各种令人衰弱的炎症性疾病和癌症。我们已经发现了一类新的药物,它可以与人类细胞上的一个新靶点结合,并阻止不受欢迎的长期炎症反应。该项目测试了一种新的策略,即生产更清洁的药物,这些药物对治疗关节炎和其他炎症性疾病、饮食导致的肥胖和癌症的新靶点具有更高的选择性和更少的副作用。
英文摘要
Infection and tissue damage provoke acute inflammatory responses that sometimes continue unchecked, leading to different kinds of debilitating inflammatory diseases and cancers. We have discovered a new class of drugs that bind to a new target on human cells and block undesirable prolonged inflammatory responses. This project tests a new strategy to produce 'cleaner' drugs that act more selectively with fewer side effects against a new target in the treatment of arthritis and other inflammatory diseases, diet-induced obesity and cancers.
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Super-resolution platform to accelerate biological and molecular research
  • 批准号:
    LE240100134
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $53.09万
  • 财政年份:
    2024
  • 负责人:
    Prof David Fairlie
  • 依托单位:
Compressing small peptides for cell absorption
  • 批准号:
    DP180103244
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $40.43万
  • 财政年份:
    2018
  • 负责人:
    Prof David Fairlie
  • 依托单位:
Combating infectious diseases by harnessing macrophage functions
  • 批准号:
    nhmrc : GNT1125316
  • 项目类别:
    Project Grants
  • 资助金额:
    $68.82万
  • 财政年份:
    2017
  • 负责人:
    Prof David Fairlie
  • 依托单位:
Modulating Protein-Protein Interactions In Disease
  • 批准号:
    nhmrc : GNT1117017
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $86.39万
  • 财政年份:
    2017
  • 负责人:
    Prof David Fairlie
  • 依托单位:
海外基金