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Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis

Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis
新发现的、不可或缺的淋巴管生成转录调节因子的表征
批准号:
nhmrc : 1107755
负责人:
A/Pr Benjamin Hogan
金额:
$36.68万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

项目摘要

项目成果

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中文摘要
翻译
淋巴管通过淋巴管生成形成:从预先存在的血管中生长出淋巴管。这一过程在转移过程中适合于治疗干预,因为代谢物支持肿瘤扩散。我们发现了一个基因是淋巴管生成的关键。我们将研究这种新因子对淋巴管生成的控制。我们的目标是了解它如何控制淋巴管的形成,并确定该途径中具有新的治疗潜力的基因。
英文摘要
Lymphatic vessels form via lymphangiogenesis: growth of lymphatics from pre-existing vessels. This process is amenable to therapeutic intervention during metastasis because lymphatics support tumour spread. We discovered a gene that is essential for lymphangiogenesis to occur. We will investigate the control of lymphangiogenesis by this new factor. We aim to understand how it controls lymphatic vessel formation and identify genes within this pathway that have novel therapeutic potential.
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Mechanisms of vascular development in health and disease
  • 批准号:
    nhmrc : GNT1155221
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    A/Pr Benjamin Hogan
  • 依托单位:
Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development
  • 批准号:
    nhmrc : 1146352
  • 项目类别:
    Project Grants
  • 资助金额:
    $67.1万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Benjamin Hogan
  • 依托单位:
Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development
  • 批准号:
    nhmrc : GNT1146352
  • 项目类别:
    Project Grants
  • 资助金额:
    $99.24万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Benjamin Hogan
  • 依托单位:
Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
  • 批准号:
    nhmrc : 1124011
  • 项目类别:
    Project Grants
  • 资助金额:
    $83.93万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Benjamin Hogan
  • 依托单位:
海外基金