Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease

胰岛素及其胰岛素样生长因子在澳大利亚老年人面临的三种主要疾病——糖尿病、癌症和阿尔茨海默病中起着重要作用。我们的目标是了解这些蛋白质如何通过所谓的受体将信息传递到细胞中。我们将从细胞中分离出受体分子，然后在先进的电子显微镜下对它们进行成像，以产生三维图像。我们的发现将对针对上述三种疾病的治疗方法的设计产生影响。

Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.