Targeting host pathogen interactions and signalling networks to promote death of infected cells and facilitate pathogen clearance

将使用包括乙肝、艾滋病毒、结核病和人类疱疹病毒感染在内的传染病的临床前模型来了解病原体如何与宿主细胞相互作用。有了这种理解，我们的目标是确定哪些宿主细胞信号通路在限制或促进病原体持久性方面发挥关键作用。在确定了重要的细胞通路后，我们的目标是用临床阶段的药物来靶向这些宿主细胞信号成分，以促进病原体的清除。

Preclinical models of infectious diseases including hepatitis B, HIV, tuberculosis and human herpes virus infections will be used to understand how pathogens interact with host cells. With this understanding we aim to identify which host cell signalling pathways play a critical role in limiting or faciliating pathogen persistence. After identifying the important cellular pathways we aim to target these host cell signalling components with clinical stage drugs to promote pathogen clearance.