Elucidation of critical characteristics of clostridium perfringens and pathogen-host-environment interactions defining susceptibility of poultry to necrotic enteritis

坏死性肠炎（Necrotic enteritis，NE）是一种重要的家禽疾病。 尽管在过去的30年里进行了大量的研究，但关于肉鸡坏死性病变的潜在病因的问题仍然没有得到解决。 据业内专家介绍，NE是一种重新出现的疾病。 此外，由于与亚临床NE相关的巨大隐藏经济成本，并且还由于病原体转移到食物链和公共卫生问题的高风险，该问题在行业专家中被视为主要问题。NE是加拿大和全球家禽业的一个重要问题。 考虑到对这种疾病的发病机制的理解存在重大差距，迫切需要启动对NE的病原体特征和病原-宿主相互作用病因学的基础研究。开发更好的方法来控制家禽中的NE肯定具有战略重要性。

Necrotic enteritis (NE) remains an important disease in poultry. Despite considerable research over the last 30 years, the issues regarding the underlying etiology of necrotic lesions in broiler chickens still remain unresolved. According to industry experts, NE is a re-emerging disease. Moreover, because of large hidden economic cost associated with sub-clinical NE, and also because of the high risk of pathogen transfer to the food chain and public health concerns, this problem is perceived among the industry experts as a major issue. NE is a problem of significant importance for the Canadian and global poultry industry. Considering the significant gaps in understanding of the pathogenesis of this disease, there is an urgent need to initiate basic research on the characteristics of pathogens and on pathogen-host interaction etiology of NE. Development of better means for controlling NE in poultry would definitely be of strategic importance.