Multi-user microscopy system for high resolution cell biology/biochemistry imaging

这项提案是为了促进整个生物和化学/生物化学系在温莎大学的研究需求。因此，它所涵盖的科学领域是多种多样的；从细胞和分子生物学/生物化学/遗传学研究领域，如生物体如何发育，细胞如何生长，分裂和调节正常和异常情况下的细胞死亡，身体如何调节其脂质/脂肪含量，细胞如何相互作用和周围环境，以及与动物如何处理气味和声音以及这如何控制对外部环境的重要反应有关的生理问题。这些研究项目都非常依赖显微镜作为分析和发布数据的终点。目前，该小组正在共享一台已有15年历史的核心设备显微镜，该显微镜已经过时，使用频繁，并且在相机分辨率和光谱成像方面的能力有限。随着我们的部门越来越多的NSERC资助的年轻教师依赖于显微镜，我们在温莎大学扩展和提高我们的成像能力是绝对必要的。获得一个核心设施显微镜，具有更新的能力，以提高的速度和分辨率成像范围广泛的不同颜色，对于促进本应用程序中描述的研究和培训的成功是绝对必要的。

This proposal is to facilitate the research needs of the entire Biology and Chemistry/Biochemistry Departments at the University of Windsor. Hence, the areas of science it encompasses are diverse; from cellular and molecular biology/biochemistry/genetics studying areas such as how organisms develop, how cells grow, divide and regulate cell death in normal and abnormal situations, how the body regulates its lipid/fat content, how cells interact with one another and the environment around them to physiological questions relating to how animals process both smell and sound and how this controls important responses to the external environment. Each of these research programs rely very heavily on microscopy as the endpoint to analyse and publish data. Currently this group is sharing a 15 year old core facility microscope which is outdated, heavily utilized and limited in its capabilities with regard to camera resolution and spectral imaging. With our Departments growing in the number of NSERC funded young faculty dependent on microscopy it is absolutely essential that we expand and improve our imaging capabilities here at the University of Windsor. Acquisition of a core facilities microscope, with updated capabilities to image a wide range of different colours at enhanced speed and with much improved resolution is absolutely essential to facilitate the success of the research and training of the programs described in this application.