High DDA Chitosan/Bacterial Cellulose Nanofibrous Structures by Electrospinning for Wound Dressing

具有纳米特征的支架可以改善许多组织的许多细胞功能， 血管、膀胱、软骨、神经、皮肤等。这些支架可以由各种材料制备，包括 合成的和天然的生物材料。在这个项目中，我们将使用二维(2D)纳米纤维 由两种天然生物聚合物，壳聚糖和细菌纤维素，使用静电纺丝和 同轴电纺工艺，在共纺剂聚氧乙烷存在的情况下。这种材料 可以赋予纳米纤维垫高弹性，这可能对关节周围的伤口愈合很重要。 我们对脱乙酰度较高(DDA)的壳聚糖更感兴趣，因为它们 具有机械性能、生物降解性、免疫学活性、 伤口愈合性能和促进成骨作用。在我们的研究小组中，我们开发了强大的 使用这一工艺制备基于壳聚糖的纳米结构的专业知识和知识库。论 另一方面，Axcelon生物聚合物公司活跃在结构和 用于伤口愈合、心脏病学、组织工程和再生医学的配方。这样做的目的是 Engage项目是开发由高DDA壳聚糖和细菌制成的弹性纳米纤维纳米结构 伤口愈合区域中的纤维素。如果结果显示有希望的潜力，那么进一步的合作 将会被开发出来。

Scaffolds with nanoscale features can improve many cells functions for a number of tissues such as bone, vascular, bladder, cartilage, neural, skin, etc. These scaffolds may be prepared from various materials including synthetic and natural based biomaterials. In this project we will use two dimensional (2D) nanofibrous structures made from two natural biopolymers, chitosan and bacterial cellulose, using the electrospinning and co-axial electrospinning processes, in the presence of a co-spinning agent, polyethylene oxide. This material can impart high elasticity to the nanofibrous mats, which may be important for wound healing around joints. We are interested more particularly in chitosans with a high degree of deacetylation (DDA) because of their advantageous characteristics such as mechanical properties, biodegradability, immunological activity, wound-healing properties, and osteogenesis enhancement. In our research group, we have developed a strong expertise and knowledge base in the preparation of nanostructures based on chitosan using this process. On the other hand, Axcelon Biopolymers Corporation is active in the area of development of structures and formulations for wound healing, cardiology, tissue engineering and regenerative medicine. The objective of this Engage project is to develop elastic nanofibrous nanostructures made from high DDA chitosans and bacterial cellulose in the area of wound healing. If the results indicate promising potential, then further collaborations will be developed.