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Hypoxia-selective inhibitors of DNA repair

Hypoxia-selective inhibitors of DNA repair
DNA 修复的缺氧选择性抑制剂
批准号：
376328
负责人：
Minchinton Andrew I
金额：
$18.9万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-11-01 至 2020-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=376328&lang=en
关键词：
Dna Repair Drug Discovery Medicinal Chemistry Prodrugs Radiation Biology Radiosenstiziation Radiotherapy Targeting Hypoxia Tumour Hypoxia Tumour Microenvironment

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中文摘要
翻译
拟议的工作包括开发一种药物，以提高放射治疗的有效性。由于放射疗法用于治疗约50%的癌症，这种药物可能会产生非常广泛的影响，提高治愈率和质量
英文摘要
The proposed work involves the development of a drug that will improve the effectiveness of radiation therapy. Since radiation therapy is used to treat about 50% of all cancers this drug could have very wide impact, improving cure rates as well as quality
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会议论文
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FLASH radiotherapy - mechanisms and translational studies
Metabolic manipulation of hypoxia for improved radiotherapy response
Hypoxia-activated DNA repair inhibitors to improve cancer therapy
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