Liquid chromatography-mass spectrometry (LCMS) instrument

所要求的液相色谱-质谱（LCMS）仪器迫切需要持续努力，在化学系（Université de Montréal，UM）在催化，药物化学，能源科学，纳米技术和环境研究等各个领域进行高影响力的发现和培训高素质的人才（HQP）。来自17位不同教授实验室的超过200名学生和博士后研究员使用的基本分析工具，前LCMS仪器于2003年由CFI基金购买，位于区域质谱中心（RMSC-UM），并作为开放获取的主力军，我们的研究人员在操作和数据处理方面接受了十多年的全面培训。除了维修，迫切需要更换，现在已经不复存在的LCMS仪器也是RMSC-UM工作人员雇用的一个重要工具，为其他学术和私营部门实验室的十几个校外客户提供服务。LCMS是化学和生物化学中一种宝贵的技能和不可或缺的研究技术，通常用于获得有关化合物组成和纯度的精确信息，以便及时做出进行/不进行研究决策，优化反应条件，确保产品质量，并评估组分化学计量。各种区域范围内的学生项目是由来自微量样品的有效分析的信息作为常规注射到开放式LCMS仪器的结果指导的。没有LCMS仪器，重要的研究正在被延迟和损害，因为我们的替代开放式分析机器缺乏在快速数据采集期间常规提供相同灵敏度和精度的能力，以指导采用现代技术的调查的明智评估和执行：例如，组合实验、固相化学和固相微萃取。迫切需要的是，开放式LCMS仪器对于与学术界和工业界同事合作研究的成功至关重要，他们等待验证用于生物研究的样品的纯度，并从环境，能源和材料科学的各种研究中寻求样品组成的信息。因此，更换这一重要的开放式LCMS仪器对于确保有价值的科学研究和培训的稳定流动，以造福加拿大的医疗保健，经济和环境至关重要。

The requested liquid-chromatography-mass spectrometry (LCMS) instrument is urgently needed to sustain efforts to make high impact discoveries and train highly qualified personnel (HQP) at the Department of Chemistry (Université de Montréal, UM) in various fields including catalysis, medicinal chemistry, energy science, nanotechnology and environmental research. An essential analytical tool that was used by >200 students and postdoctoral fellows from the laboratories of 17 different professors, the former LCMS instrument was purchased with CFI funds in 2003, housed in the Regional Mass Spectrometry Centre (RMSC-UM), and served as an open-access workhorse on which our researchers were fully trained in operation and data handling for over a decade. Beyond repair, desperately needing replacement, the now defunct LCMS instrument was also an essential tool employed by RMSC-UM staff to service over a dozen clients from outside the university in other academic and private sector laboratories. A valuable skill set and indispensable research technique in chemistry and biochemistry, LCMS is routinely employed to obtain precise information on compound composition and purity for timely making go/no-go research decisions, to optimize reaction conditions, to ensure product quality, and to assess component stoichiometry. Various region-wide student projects are guided by information from efficient analysis of miniscule amounts of sample as a result of routine injection into an open-access LCMS instrument. Without the LCMS instrument, important research is being delayed and compromised because our alternative open-access analytical machines lack the capacity to routinely provide the same sensitivity and precision during rapid data acquisition to guide the judicious evaluation and execution of investigations employing modern techniques: e.g., combinatorial experimentation, solid-supported chemistry, and solid-phase micro extraction. Urgently needed, an open-access LCMS instrument is essential for the success of collaborative research with academic and industrial colleagues, who await validation of the purity of samples destined for biological studies, and who seek information on sample composition from diverse research in environment, energy and materials science. Replacement of this vital open-access LCMS instrument is thus critical to ensure a steady flow of valuable scientific research and training for the benefit of Canada's healthcare, economy and environment.*****