Carbohydrates, enzymes and natural products

杰克曼国家科学研究委员会发现研究资助计划将在生物化学方面进行基础科学发现。这些发现将对理解酶的机制产生重大影响，酶是自然界主要的催化剂。它着重于酶，催化的反应在自然科学中无处不在的重要性。它将为抑制特定酶类或产生更大底物特异性的新方法提供见解。其中一些酶负责产生次级代谢物，这些小分子具有与自然界相互作用的前所未有的能力。我们对酶的研究包括范式转换方法，以合理地改变结构，从而赋予天然产物不同的物理化学性质。该研究项目将为本科生、研究生（硕士和博士）和PDF学员提供良好的培训环境。学员将在多个领域发展技能，包括：碳水化合物合成、酶学、天然产物分离和结构解析。学员将在一个相互尊重的学习环境中学习，日常指导、讨论和解决问题是至关重要的。我们会及时鼓励他们，并就书面和口头研究结果给予反馈，以确保他们发挥最大的潜力。不同培训层次的受训者之间的合作将加强沟通技巧，提高解决问题的能力。学员将学习与现实世界相关的研究技能，以便在完成培训后为他们提供最佳机会。学员将继续参加强调《权利宪章》的讲习班，主题包括公平、多元化和包容（EDI）、大湾区+、性别偏见和无意识偏见，以最大限度地提高培训环境，使他们更好地为职场做好准备。在过去的NSERC资助期间，Jakeman实验室培养了9名本科生，4名硕士，3名博士和6名pdf，其中包括3名来自欧洲的本科生访问学生。在Jakeman小组中，受训者是富有成效的：他们已经撰写了34篇手稿。他们在离开时获得的职位也很好。两位前博士学员现为pdf。一个在密歇根大学，另一个在UBC，在旧金山Codexis公司担任研究科学家。在那里，她将应用诺贝尔化学奖得主弗朗西斯·阿诺德的定向进化来设计蛋白质生物催化剂。两名前理学硕士学生正在渥太华和麦吉尔大学攻读博士学位。来自Jakeman实验室的学员也给加拿大工业界的高管们留下了深刻的印象，Intellisyn（蒙特利尔）最近招募了PDF。

The Jakeman NSERC Discovery research grant program will make fundamental scientific discoveries in biological chemistry. These discoveries will have a significant impact on understanding the mechanisms of enzymes, Nature's predominant catalysts. It focuses upon enzymes that catalyze reactions of ubiquitous importance within the natural sciences. It will provide insight into new ways to inhibit specific enzyme classes or to generate greater substrate specificity. Some of these enzymes are responsible for the production of secondary metabolites, small molecules that have unprecedented capacity to interact with the natural world. Our studies on the enzymes include paradigm shifting methods to rationally alter the structures, and hence confer different physicochemical properties, of natural products. The program of research will provide an excellent training environment for undergraduate, graduate (MSc and PhD) and PDF trainees. Trainees will develop skills in multiple areas including: carbohydrate synthesis, enzymology, and natural products isolation and structure elucidation. Trainees will be part of a respectful learning environment where daily guidance, discussion and problem-solving are of paramount importance. They will be provided with timely encouragement and feedback on written and oral research results to ensure that they achieve their maximum potential. Collaboration between trainees at different levels of training will strengthen communication skills and improve problem-solving. Trainees will learn research skills relevant to the real-world to provide them with optimum opportunities upon completion of training. Trainees will continue to participate in workshops emphasising the charter of rights with topics including equity, diversity and inclusion (EDI), GBA+, gender bias, and unconscious bias to maximize the training environment and better prepare them for the workplace. Over the past NSERC funding period, the Jakeman laboratory has trained 9 undergraduates, 4 MSc, 3 PhD students and 6 PDFs, including three undergraduate visiting students from Europe. Trainees are productive in the Jakeman group: 34 manuscripts have been authored by them. The positions they secure upon departure are also excellent. Two former PhD trainees are currently PDFs. One is at the University of Michigan, and another at UBC transitioning to a research scientist position with Codexis, San Francisco. There she will apply Chemistry Nobel Laureate Francis Arnold's directed evolution to engineer protein biocatalysts. Two former MSc students are pursuing PhD research at Ottawa and McGill. Executives in Canadian industry are also impressed by trainees from the Jakeman lab with the most recent PDF being recruited by Intellisyn (Montreal).