Organofluorine Chemistry: From New Synthetic Methods to New Reactivity

氟的独特性质是为什么这个原子和氟化基团（CF3、CF2H等）现在是化学生物学、药物化学、农业化学和材料科学中应用的有机化合物的关键取代基的关键。这一领域需要对氟化分子的反应性有更深入的基本了解，并需要创新、实用的合成方法。我的研究计划的长期愿景是为有机氟分子的合成提供最先进的方法，并扩大对这类独特化合物的反应性/行为的集体知识。在上一个资助期内，我们取得了重大进展，改善了合成、药物和生物有机化学。这个发现基金的续期将继续这个成功的计划。我们计划在未来五年内集中精力在三个具有重大影响潜力的主要研究领域：1)探索五氟磺酰化化合物合成的新领域；2)利用C-F键作为指导基团；3)改进单氟烯烃的合成

The unique properties of fluorine are key in why this atom and fluorinated groups (CF3, CF2H, etc.) are now key substituents on organic compounds for applications in chemical biology, in medicinal chemistry, in agrochemistry, and in the material sciences. This field needs a deeper fundamental understanding of fluorinated molecule reactivity, and innovative, practical methods for their synthesis. The long-term vision of my research program is to contribute state-of-the-art methods for the synthesis of organofluorine molecules, and to broaden the collective knowledge of the reactivity/behaviour of this unique class of compounds. During the last funding period, we accomplished significant advances that have improved synthetic, medicinal, and bioorganic chemistry. This Discovery Grant renewal will continue this successful program. We intend to concentrate our efforts in the next five years in three major research areas with significant high-impact potential: 1) Exploring new frontiers in the synthesis of pentafluorosulfanylated compounds 2) Exploiting the C-F bond as a directing group 3) Improving the synthesis of monofluoroalkenes