New analgesics based on µ-conotoxins: structure-based design of helical mimetics

涉及电压门控钠通道的疾病是导致澳大利亚人口发病率和死亡率的因素，该项目有望为未来治疗此类疾病的药物开发提供新的线索，特别是用于治疗慢性疼痛的镇痛药。这些线索的产生将需要开发新的方法来模拟药物样分子中肽和蛋白质的关键区域。这是一个高度跨学科的项目，涵盖结构生物学、分子设计、药物化学、分子生物学和电生理学，培养具有如此广泛经验的博士毕业生是该项目的另一个国家利益。

Diseases in which voltage-gated sodium channels are implicated are contributors to morbidity and mortality in the Australian population, and this project promises to provide new leads for the future development of drugs to treat such diseases, in particular analgesics for the treatment of chronic pain. The generation of these leads will entail the development of new approaches to mimicking key regions of peptides and proteins in drug-like molecules. This is a highly interdisciplinary project, spanning structural biology, molecular design, medicinal chemistry, molecular biology and electrophysiology, and the training of PhD graduates with such broad experience represents another national benefit of the project.