Acquisition of a 500 MHz NMR Spectrometer

购买 500 MHz NMR 波谱仪

• 批准号: 8815047
• 负责人: Frederick Dahlquist
• 金额: $ 3万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8815047&HistoricalAwards=false
• 关键词: Acquisition; 500; MHz; NMR; Spectrometer

Partial funding for the purchase of a shared 500 MHz NMR spectrometer is requested. The proposed instrument will greatly aid in the nine research projects outlined in this proposal. These include the structure and dynamics of bacteriophage T4 lysozyme; the structure of the "zinc finger" of bacteriophage T4 gene 32 protein; the nature of the interactions of tetraalkylammonium compounds with DNA; the structure of a determinant in the sorting of yeast carboxypeptidase to the vacuole; the structure and thermodynamic properties of an aspartic acid residue involved in proton pumping by the F1/F0 ATPase; an investigation of the direct transfer of substrates between enzymes; the synthesis of biologically important compounds; the mechanism of action of coenzyme B12; and the structure and mechanism of inhibition of serine proteases by selenoxide containing compounds.

请求提供部分资金，用于购买共享的500兆赫核磁共振光谱仪。拟议的文书将极大地帮助本提案中概述的九个研究项目。这些研究包括：噬菌体T4溶菌酶的结构和动力学；噬菌体T4基因32蛋白的“锌指”结构；四烷基铵化合物与DNA相互作用的性质；酵母羧肽酶分选到液泡的决定因素的结构；参与F1/F0 ATPase质子泵的天冬氨酸残基的结构和热力学性质；研究底物在酶之间的直接转移；生物重要化合物的合成；辅酶B12的作用机制；以及含硒化合物抑制丝氨酸蛋白酶的结构和机制。