Acquisition of a 500 MHz NMR Spectrometer

这是一个购买500兆赫核磁共振的建议， 共振分光计 光谱仪将用于 研究蛋白质折叠的基本问题， 结构 出色的水抑制，如获得与 现代脉冲整形能力，以及非常好的分辨率， 是必需品。 这些项目包括调查 蛋白酶抑制剂-蛋白酶复合物的结构， 核酸的相互作用，以及 蛋白质运动和生物反应速率常数 电子转移

This is a proposal to purchase a 500 MHz nuclear magnetic resonance spectrometer. The spectrometer will be used to study fundamental questions in protein folding and structure. Excellent water suppression, as obtained with modern pulse shaping capabilities, and very good resolution, are necessities. The projects include investigations of the structure of protease inhibitor-protease complexes, the interaction of nucleic acids, and the relationship between protein motions and the rate constants of biological electron transfer.