Acquisition of a 400 MHz NMR Spectrometer

购买 400 MHz NMR 波谱仪

• 批准号: 9413721
• 负责人: David Graves
• 金额: $ 17.5万
• 依托单位: University of Mississippi
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 1996-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9413721&HistoricalAwards=false
• 关键词: Acquisition; 400; MHz; NMR; Spectrometer

Funds are requested for the purchase of a 400 MHz NMR spectrometer for the Department of Chemistry at the University of Mississippi. Acquisition of this spectrometer will greatly enhance ongoing research programs in areas of organic, inorganic, biochemistry, and biophysics within this department. The core user group requires a higher-field NRM spectrometer with more advanced pulse techniques than is currently available in the Department of Chemistry to extend our studies involving large molecules such as proteins, oligonucleotides and related species as well as structurally complex "small" organic molecules. Specific applications of five core users include (1) the study of ligand- oligonucleotide interactions, (2) polypeptide structures using conformationally contrained amino acid analogs, (3) structual analysis of alkane thiols used to form self- assembled monolayers, (4) structural analyses of organic donor-acceptor molecules, (5) structural elucidation of biologically active natural products.

请求提供资金，为密西西比大学化学系购买一台400兆赫核磁共振分光计。 购买这台光谱仪将大大加强正在进行的研究计划，在有机，无机，生物化学和生物物理领域内的这个部门。 核心用户组需要一个更高的领域NRM光谱仪与更先进的脉冲技术比目前在化学系扩展我们的研究涉及大分子，如蛋白质，寡核苷酸和相关物种以及结构复杂的“小”有机分子。 五个核心用户的具体应用包括（1）配体-寡核苷酸相互作用的研究，（2）使用构象约束的氨基酸类似物的多肽结构，（3）用于形成自组装单分子层的烷硫醇的结构分析，（4）有机供体-受体分子的结构分析，（5）生物活性天然产物的结构解析。