A 600 MHz Nuclear Magnetic Resonance Spectrometer

600 MHz 核磁共振波谱仪

• 批准号: 9522677
• 负责人: Roy Gordon
• 金额: $ 28.21万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9522677&HistoricalAwards=false
• 关键词: 600; MHz; Nuclear; Magnetic; Resonance

Funds are requested to purchase a state-of-the-art 600 MHz nuclear magnetic resonance spectrometer with triple- resonance and pulse-field gradient accessories to be used by three major groups in the Department of Chemistry and the Department of Molecular and Cellular Biology, and by several minor users in the Department of Chemistry This instrument is needed to provide high-resolution and high-sensitivity homo-nuclear multi-dimensional NMR capabilities for carrying out many new NIH-funded research projects and several new directions derived from existing NIH-funded projects. Theses include structural and functional studies of signaling proteins, transcriptional regulation and DNA repair by proteins, and structural immunology and virology, all of which rely on successful determination of three-dimensional structures of biological macromolecules in solution.

请拨经费购买一台最先进的600兆赫核磁共振光谱仪，配有三共振和脉冲场梯度附件，供化学系和分子和细胞生物系的三个主要小组使用；该仪器需要提供高分辨率和高灵敏度的同核多维核磁共振能力，以开展许多新的美国国立卫生研究院资助的研究项目和一些来自现有美国国立卫生研究院资助的项目的新方向。论文包括信号蛋白的结构和功能研究、蛋白质的转录调控和DNA修复、结构免疫学和病毒学，所有这些都依赖于对溶液中生物大分子三维结构的成功测定。