Upgrade of an NMR Spectrometer

小行星9312233 化学研究仪器计划的这个奖项 将协助哈佛大学化学系 购买一个500兆赫的多核 核磁共振（NMR）光谱仪。此次升级将 大力加强若干领域的研究，包括 以下内容： 1)有趣和具有挑战性的分子的全合成 例如：（a）miroestrol，一种结构新颖成分， 具有有趣生物学特性的东方草药， (b)芍药苷，一种复杂的多环植物葡糖苷，和（c） 肿瘤血管生成抑制剂如卵蒜素， 2)海葵毒素的天然产物合成， 3)C-和O-糖苷的构象研究， 4)聚醚大环内酯软海绵素， 5)信号蛋白的结构和功能研究， 6)核酸的结构和机制研究， 核酸结合蛋白， %%% 核磁共振（NMR）光谱仪用于 获得有关分子结构的信息（什么类型的 存在碳和/或氢原子和/或杂原子， 每种类型的原子的相对数量是多少， 它们在分子中相互连接）和分子 动力学（分子的各个部分有多快 移动）。 这项文书对于任何有意义的、 现代合成化学研究计划 ***

9312233 Gordon This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at Harvard University in the purchase of an upgrade for a 500 MHz, multinuclear, nuclear magnetic resonance (NMR) spectrometer. This upgrade will enhance greatly research in a number of areas including the following: 1) Total synthesis of interesting and challenging molecules such as: (a) miroestrol, a structurally novel ingredient of an oriental medicinal herb with interesting biological properties, (b) paeoniflorin, a complex polycyclic plant glucoside and (c) inhibitors of tumor angiogenesis such as ovalicin, 2) Natural product synthesis of palytoxin, 3) Conformational studies of C- and O-glycosides, 4) Polyether macrolide halichondrins, 5) Structural and functional studies of signaling proteins, 6) Structural and mechanistic studies of nucleic acids and nucleic-acid binding proteins, %%% A nuclear magnetic resonance (NMR) spectrometer is used to obtain information about molecular structure (what types of carbon and/or hydrogen atoms and/or hetero-atoms are present, what are the relative number of each type of atoms and how are they connected to one another in the molecule) and molecular dynamics (how rapidly are the various parts of the molecule moving). This instrument is essential for any meaningful, modern synthetic chemistry research program. ***