Upgrade of an NMR Spectrometer

核磁共振波谱仪的升级

• 批准号: 9312233
• 负责人: Roy Gordon
• 金额: $ 26.54万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312233&HistoricalAwards=false
• 关键词: Upgrade; NMR; Spectrometer

9312233 Gordon This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at Harvard University in the purchase of an upgrade for a 500 MHz, multinuclear, nuclear magnetic resonance (NMR) spectrometer. This upgrade will enhance greatly research in a number of areas including the following: 1) Total synthesis of interesting and challenging molecules such as: (a) miroestrol, a structurally novel ingredient of an oriental medicinal herb with interesting biological properties, (b) paeoniflorin, a complex polycyclic plant glucoside and (c) inhibitors of tumor angiogenesis such as ovalicin, 2) Natural product synthesis of palytoxin, 3) Conformational studies of C- and O-glycosides, 4) Polyether macrolide halichondrins, 5) Structural and functional studies of signaling proteins, 6) Structural and mechanistic studies of nucleic acids and nucleic-acid binding proteins, %%% A nuclear magnetic resonance (NMR) spectrometer is used to obtain information about molecular structure (what types of carbon and/or hydrogen atoms and/or hetero-atoms are present, what are the relative number of each type of atoms and how are they connected to one another in the molecule) and molecular dynamics (how rapidly are the various parts of the molecule moving). This instrument is essential for any meaningful, modern synthetic chemistry research program. ***

这份来自化学研究仪器项目的合同将帮助哈佛大学化学系升级一台500兆赫多核核磁共振（NMR）光谱仪。这一升级将大大加强在许多领域的研究，包括：1)有趣和具有挑战性的分子的全合成，如：(a)微雌酚，一种结构新颖的东方草药成分，具有有趣的生物学特性；(b)芍药苷，一种复杂的多环植物糖苷；(c)肿瘤血管生成抑制剂，如卵黄霉素；(2)palytoxin的天然产物合成；核酸和核酸结合蛋白的结构和机理研究使用核磁共振（NMR）波谱仪来获得分子结构（存在什么类型的碳和/或氢原子和/或杂原子，每种原子的相对数量以及它们在分子中如何相互连接）和分子动力学（分子各部分运动的速度有多快）的信息。这个仪器对于任何有意义的现代合成化学研究计划都是必不可少的。＊＊＊