Organometallic Oxidation Chemistry

有机金属氧化化学

• 批准号: 9530544
• 负责人: James Mayer
• 金额: $ 35.5万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9530544&HistoricalAwards=false
• 关键词: Organometallic; Oxidation; Chemistry

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program provides continuing support to research on the mechanism of oxidation reactions of organometallic compounds by Dr. James M. Mayer of the Chemistry Department, University of Washington. The formation of carbon-oxygen bonds using a metal-oxo group as the oxygen source is the focus of the investigation. The migration of aryl and alkyl groups from a metal center to an oxo group--an important step in the reaction mechanism--will be explored in detail. A variety of reactions involving intra- and inter- molecular nucleophilic attack at oxo groups will be studied. The rhenium-oxo-hydridotris(pyrazolyl)borate system will be used to generate, isolate, and study migrations involving electrophilic oxo groups. The oxidizing rhenium(VII) compounds are formed by oxygen atom transfer to stable rhenium(V) compounds. Other studies will explore the range of these reactions, including alkyl, alkene, arene, and thioether oxidations. Oxidation is an important commercial process in applications ranging from pharmaceutical synthesis to waste treatment, but the ability to control oxidation reactions is limited. This project addresses fundamental issues concerning mechanisms of oxidation of organic substances and will have impact on the ability to control organic oxidations. .

无机化学、生物无机化学和金属有机化学项目的这一奖项为华盛顿大学化学系的James M.Mayer博士对有机金属化合物氧化反应机理的研究提供了持续的支持。以金属氧基为氧源的碳氧键的形成是研究的重点。将详细探讨芳基和烷基从金属中心到氧基的迁移--反应机理中的一个重要步骤。将研究涉及分子内和分子间对氧基团的亲核攻击的各种反应。Re-氧-氢-三(吡唑基)硼酸盐体系将被用来产生、分离和研究涉及亲电氧基的迁移。氧化态Re(VI)化合物是通过氧原子转移到稳定的Re(V)化合物中形成的。其他研究将探索这些反应的范围，包括烷基、烯烃、芳烃和硫醚氧化。氧化是一种重要的商业过程，从药物合成到废物处理，但控制氧化反应的能力是有限的。该项目涉及有关有机物质氧化机制的基本问题，并将对控制有机氧化的能力产生影响。。