Organometallic Oxidation Chemistry

该奖项在无机，生物无机和有机化学 该计划提供持续的支持，以研究的机制， 有机金属化合物的氧化反应。市长 华盛顿大学化学系。 的形成 使用金属-氧代基团作为氧源的碳-氧键是 调查的重点。 芳基和烷基基团从 一个金属中心连接到一个氧代基上--这是反应的重要步骤 机制-将进行详细探讨。 各种反应，包括 在氧代基团上分子内和分子间亲核攻击将 研究了 所述三（吡唑基）硼酸鎓-氧代-三（吡唑基）硼酸鎓体系将是 用于生成、分离和研究涉及亲电性的迁移 氧代基团。 氧化性化合物由氧形成 原子转移到稳定的化合物。 其他研究将探索 这些反应的范围，包括烷基、烯烃、芳烃和 硫醚氧化。 氧化是一种重要的商业方法，应用范围从 药物合成废物处理，但控制能力 氧化反应受到限制。 该项目涉及基础 关于有机物氧化机理的问题， 影响控制有机氧化的能力。 .

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program provides continuing support to research on the mechanism of oxidation reactions of organometallic compounds by Dr. James M. Mayer of the Chemistry Department, University of Washington. The formation of carbon-oxygen bonds using a metal-oxo group as the oxygen source is the focus of the investigation. The migration of aryl and alkyl groups from a metal center to an oxo group--an important step in the reaction mechanism--will be explored in detail. A variety of reactions involving intra- and inter- molecular nucleophilic attack at oxo groups will be studied. The rhenium-oxo-hydridotris(pyrazolyl)borate system will be used to generate, isolate, and study migrations involving electrophilic oxo groups. The oxidizing rhenium(VII) compounds are formed by oxygen atom transfer to stable rhenium(V) compounds. Other studies will explore the range of these reactions, including alkyl, alkene, arene, and thioether oxidations. Oxidation is an important commercial process in applications ranging from pharmaceutical synthesis to waste treatment, but the ability to control oxidation reactions is limited. This project addresses fundamental issues concerning mechanisms of oxidation of organic substances and will have impact on the ability to control organic oxidations. .