Reactions at Ligands in Strongly Oxidizing Metal Complexes

强氧化性金属配合物中配体的反应

• 批准号: 0204697
• 负责人: James Mayer
• 金额: $ 43.3万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0204697&HistoricalAwards=false
• 关键词: Reactions; Ligands; Strongly; Oxidizing; Metal

This award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by James Mayer, Department of Chemistry, University of Washington, in the fundamental processes of transition metal-promoted oxidations. The properties and reactivity of a new osmium compound, tris(pyrazolyl)borate osmium dioxo nitride will be studied. This compound has shown olefin dihydroxylation activity. Novel electrophilic reactions of coordinated ligands will be explored, starting from the unique attack of an anilido ligand bound to osmium. Mayer will also extend his work into high oxidation state ruthenium and iridium complexes. In these strongly oxidizing complexes, ligands that are usually electrophiles act as nucleophiles and show unusual reactivity.The selective oxidation of organic compounds by transition metal reagents and catalysts is of fundamental and technological importance. Selective oxidation is a key part of the production of many commodity chemicals, specialty organic chemicals and pharmaceuticals, and there is much room for improvement in these processes. Undergraduate and graduate students will also be trained in this important research area that combines synthetic and mechanistic chemistry.

该奖项由无机，生物无机和有机化学计划支持詹姆斯迈耶，化学系，华盛顿大学，在过渡金属促进氧化的基本过程的研究。本文研究了一种新的锇化合物--三（吡唑基）硼酸二氧氮化锇的性质和反应活性。该化合物已显示出烯烃二羟基化活性。新的亲电反应的配位体将被探索，从独特的攻击苯胺配位体结合到锇。Mayer还将把他的工作扩展到高氧化态钌和铱络合物。在这些强氧化性配合物中，通常是亲电子的配体作为亲核试剂，表现出不寻常的反应活性。过渡金属试剂和催化剂对有机化合物的选择性氧化具有重要的基础和技术意义。选择性氧化是许多商品化学品、特种有机化学品和药物生产的关键部分，这些工艺有很大的改进空间。本科生和研究生也将在这个重要的研究领域，结合合成和机械化学培训。