Reactions at Ligands in Strongly Oxidizing Metal Complexes

该奖项由无机、生物无机和有机金属化学项目颁发，支持华盛顿大学化学系James Mayer在过渡金属促进氧化的基本过程方面的研究。研究了一种新型锇化合物三（吡唑基）硼酸二氧氮化锇的性质和反应性。该化合物具有烯烃二羟基化活性。从与锇结合的苯胺配体的独特攻击开始，探索配体的新型亲电反应。梅尔还将把他的工作扩展到高氧化态的钌和铱络合物。在这些强氧化配合物中，通常为亲电试剂的配体充当亲核试剂，表现出不同寻常的反应活性。过渡金属试剂和催化剂对有机化合物的选择性氧化具有重要的基础和技术意义。选择性氧化是许多商品化学品、特种有机化学品和药品生产的关键环节，这些工艺还有很大的改进空间。本科生和研究生也将在这个结合了合成化学和机械化学的重要研究领域接受培训。

This award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by James Mayer, Department of Chemistry, University of Washington, in the fundamental processes of transition metal-promoted oxidations. The properties and reactivity of a new osmium compound, tris(pyrazolyl)borate osmium dioxo nitride will be studied. This compound has shown olefin dihydroxylation activity. Novel electrophilic reactions of coordinated ligands will be explored, starting from the unique attack of an anilido ligand bound to osmium. Mayer will also extend his work into high oxidation state ruthenium and iridium complexes. In these strongly oxidizing complexes, ligands that are usually electrophiles act as nucleophiles and show unusual reactivity.The selective oxidation of organic compounds by transition metal reagents and catalysts is of fundamental and technological importance. Selective oxidation is a key part of the production of many commodity chemicals, specialty organic chemicals and pharmaceuticals, and there is much room for improvement in these processes. Undergraduate and graduate students will also be trained in this important research area that combines synthetic and mechanistic chemistry.