Oxidations by Electrophilic Multiply Bonded Ligands

无机化学、生物无机化学和金属有机化学项目的这一奖项支持华盛顿大学化学系的詹姆斯·M·梅耶尔博士对金属介导的氧化反应的研究。当来自络合物中其他位置或来自其他分子的亲核剂与亲电的氧、氮或亚胺配体反应时，金属被正式还原，而亲核剂被氧化。在这些情况下，氧化的位置是金属和配体之间的多重键。这项研究的目的是确定配体的亲电性如何通过金属中心的变化来调节。将研究碳负离子、硼烷和烯烃的氧化，并确定反应机理。将制备新的氧化剂，包括Os(VI)和Os()-氧配合物。过渡金属选择性氧化有机化合物是生产包括药品在内的许多商品化学品的关键步骤，在废物处理中正变得越来越重要。要改进目前的技术，需要了解关键反应步骤。这项研究旨在阐明一类此类金属介导的氧化反应的化学。所有级别的学生都将参与研究，并将学习许多不同的仪器方法和实用的实验室技能。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on metal-mediated oxidation reactions by Dr. James M. Mayer of the Chemistry Department, University of Washington. When nucleophiles, either from other sites in the complex or from other molecules, react with electrophilic oxo, nitrido, or imido ligands, the metal is formally reduced and the nucleophile is oxidized. In these cases, the site of oxidation is the multiple bond between the metal and the ligand. The goal of this research is to determine how the ligand electrophilicity can be tuned by changes at the metal center. Oxidations of carbanions, boranes and alkenes will be studied and the reaction mechanisms determined. New oxidants will be prepared, including osmium (VI)- and osmium (VIII)-oxo complexes.Selective oxidation of organic compounds by transition metals is a critical step in the production of many commodity chemicals, including pharmaceuticals, and is gaining importance in waste treatment. Understanding key reaction steps is needed to improve present technology. This research is aimed at elucidating the chemistry of one class of such metal-mediated oxidation reactions. Students at all levels will be involved in the research and will learn many different instrumental methods and practical laboratory skills.