Plasma-Assisted Surface Modification of Polymers for Medical Applications

医疗应用聚合物的等离子体辅助表面改性

• 批准号: 0085156
• 负责人: Kyriakos Komvopoulos
• 金额: $ 35万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0085156&HistoricalAwards=false
• 关键词: Plasma; Assisted; Surface; Modification; Polymers

0085156KomvopoulosRecent demands for polymers exhibiting chemical inertness, low adhesion (friction), high wear resistance, and good biocompatibility have necessitated the discovery of surface treatments that can alter the physicochemical surface properties of polymers without affecting the bulk characteristics. This research is on plasma-assisted modification of the surface chemistry and microstructure of various polymer materials used in the medical field(i.e., polyethylene, polyurethane, polycarbonate, polymethylmethacrylate, and polystyrene). The proposed research will utilize state-of-the-art plasma-assisted surface modification, microanalysis, and tribotesting techniques suitable for evaluating the material response at different scales. The novelty of the proposed surface modification method stems from the use of different plasma compositions to modify, in a controlled fashion, the surface chemistry (e.g., crafting of low-surface long-chain molecules in the near-surface region) of the polymers. Since the resulting surface properties and chemical state strongly depend on controlling process conditions, basic research elucidating the effects of plasma treatment parameters (e.g., power density, plasma composition, working pressure, and gas flow rate) on the chemical behavior (e.g., crafting of protein friendly molecules, surface energy, and degree of hydrophilicity) and tribological properties of the polymers will be conducted. The ultimate objective is to develop a plasma treatment technique that enables modification of the surface chemistry, microstructure, and mechanical/tribological properties of polymers used in various medical applications. Specifically, in addition to obtaining insight into the surface characteristics of plasma-treated polymers, the information derived from this research should have direct implications to the fabrication of low-friction catheters for non-invasive cardiovascular treatment and design of wear-resistant artificial joints exhibiting good biocompatibility.

0085156 Komvopoulos最近对具有化学惰性、低粘附性（摩擦）、高耐磨性和良好生物相容性的聚合物的需求使得发现可以改变聚合物的物理化学表面性质而不影响本体特性的表面处理成为必要。 本研究是关于等离子体辅助改性用于医疗领域的各种聚合物材料的表面化学和微观结构（即，聚乙烯、聚氨酯、聚碳酸酯、聚甲基丙烯酸甲酯和聚苯乙烯）。 拟议的研究将利用最先进的等离子体辅助表面改性，微观分析和摩擦测试技术，适用于评估不同尺度的材料响应。 所提出的表面改性方法的新奇源于使用不同的等离子体组合物以受控的方式改性表面化学（例如，低表面长链分子在近表面区域的加工）。 由于所得的表面性质和化学状态强烈依赖于控制工艺条件，因此阐明等离子体处理参数（例如，功率密度、等离子体成分、工作压力和气体流速）对化学行为的影响（例如，蛋白质友好分子的制造、表面能和亲水性程度）和聚合物的摩擦学性质。 最终目标是开发一种等离子体处理技术，能够对各种医疗应用中使用的聚合物的表面化学、微观结构和机械/摩擦学性能进行改性。 具体来说，除了获得洞察等离子体处理的聚合物的表面特性，从这项研究中得到的信息应该有直接的影响，以制造低摩擦导管的非侵入性心血管治疗和耐磨人工关节的设计表现出良好的生物相容性。