An 800 MHz NMR Cryoprobe for the New Jersey Statewide NMR Facility

用于新泽西州核磁共振设施的 800 MHz 核磁共振冷冻探头

• 批准号: 0403062
• 负责人: Jean Baum
• 金额: --
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0403062&HistoricalAwards=false
• 关键词: 800; MHz; NMR; Cryoprobe; New

This grant partially supports the acquisition of an 800 MHz NMR cryoprobe to be sited at Rutgers University, Busch science campus. The cryoprobe technology will initially serve a minimum of four New Jersey institutions including Rutgers-New Brunswick (NB), Rutgers-Newark, Princeton University and Montclair State University (MSU). Eleven faculty members, three from Rutgers-NB/RWJ, two from Rutgers-Newark, four from Princeton and two from MSU are participating in the New Jersey Wide 800 MHz NMR Facility. Hands-on NMR experiments will be performed by approximately 60 graduate students and postdocs, as well as undergraduates involved in NMR research. The NMR facility will also have significant impact on research and teaching of additional faculty members in New Jersey through the research collaborations with the faculty and students in the facility. The research activities of the users of the facility are in molecular biophysics with emphasis in the following areas: Protein structure determination; Conformational studies and dynamics of folded and unfolded proteins to understand the basis of protein folding and misfolding and their associated medical disorders; Studies of nucleic acid structure and interactions; NMR investigations of protein-protein and protein-nucleic acid interactions; Design and informational analysis of small bio-medically important peptides; and NMR methods development for next generation application.

这笔赠款部分支持收购一个800兆赫核磁共振冷冻探针将设在罗格斯大学，布施科学校园。 冷冻探针技术最初将服务于至少四个新泽西机构，包括罗格斯-新不伦瑞克（NB），罗格斯-纽瓦克，普林斯顿大学和蒙特克莱尔州立大学（MSU）。 11名教员，3名来自罗格斯-NB/RWJ，2名来自罗格斯-纽瓦克，4名来自普林斯顿，2名来自密歇根州立大学，正在参加新泽西宽800 MHz核磁共振设施。 动手NMR实验将由大约60名研究生和博士后，以及参与NMR研究的本科生进行。 NMR设施也将通过与该设施的教师和学生的研究合作，对新泽西的其他教师的研究和教学产生重大影响。 该设施用户的研究活动是分子生物物理学，重点是以下领域：蛋白质结构测定;折叠和未折叠蛋白质的构象研究和动力学，以了解蛋白质折叠和错误折叠的基础及其相关的医学疾病;核酸结构和相互作用研究;蛋白质-蛋白质和蛋白质-核酸相互作用的核磁共振研究;小生物医学重要肽的设计和信息分析;以及下一代应用的NMR方法开发。