Acquisition of an 800 MHz NMR Spectrometer for a New Jersey Statewide Facility

为新泽西州设施采购 800 MHz NMR 波谱仪

• 批准号: 0320746
• 负责人: Jean Baum
• 金额: --
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320746&HistoricalAwards=false
• 关键词: Acquisition; 800; MHz; NMR; Spectrometer

A grant has been awarded to Rutgers University under the direction of Dr. Jean Baum to purchase an 800 MHz NMR spectrometer as part of an initiative to develop a New Jersey State-Wide 800 MHz NMR Facility. The 800 MHz NMR will initially serve a minimum of four New Jersey institutions including Rutgers-New Brunswick (NB), Rutgers-Newark, Princeton University and Montclair State University (MSU). Ten faculty members, three from Rutgers-NB/RWJ, one from Rutgers-Newark, four from Princeton and two from MSU are participating in the New Jersey Wide 800 MHz NMR Facility. Access to an 800 MHz NMR will allow the State-Wide group to implement a range of state of the art biological NMR experiments that are currently not feasible on the 500 and 600 MHz NMRs and will enhance their productivity in terms of time intensive NMR projects. Establishment of the NJ State-Wide 800 MHz NMR Facility will enhance the quality and accessibility of NMR research and education to the NJ community. State of the art NMR research which cannot presently be performed on the lower field instruments that exist at the respective individual institutions will now be accessible to the New Jersey NMR community. In addition, the NJ-State wide 800 MHz NMR facility provides an opportunity for undergraduates, graduates and postdocs to meet researchers from other New Jersey schools, to be trained on state of the art NMR instrumentation and to be exposed to many different NMR research projects. Having the 800 MHz NMR serve a number of different institutions provides an intellectual environment and collaborative framework for NMR users. 'Hands on' NMR experiments will be performed by approximately 60 graduate students, postdocs as well as undergraduates involved in NMR research. The research activities of the members of the facility are in molecular biophysics with emphasis in the following areas: Protein structure determination; Conformational studies and dynamics of folded and unfolded proteins to understand the basis of protein folding and misfolding; Studies of nucleic acid structure and interactions; NMR investigations of protein-protein and protein-nucleic acid interactions; Design and conformational analysis of small peptides; NMR methods development for next generation application. The New Jersey Statewide 800 MHz NMR facility that we will establish will provide infrastructure and enhance the quality and accessibility for many research and educational programs at both private and public Universities in New Jersey. In bringing together this group of Universities, we are establishing an environment of collaboration and are coordinating expertise in NMR from many different institutions. The NJ wide 800 MHz NMR facility provides an opportunity for undergraduates, graduates and postdocs to meet researchers from other New Jersey schools and to be exposed to many different NMR research projects. Having the 800 MHz NMR serve a number of different institutions provides an intellectual environment and collaborative framework for NMR users.

罗格斯大学（Rutgers University）在Jean Baum博士的指导下获得了一笔赠款，用于购买一台800 MHz核磁共振光谱仪，作为开发新泽西州范围内800 MHz核磁共振设备的倡议的一部分。800兆赫的核磁共振最初将至少服务于新泽西州的四所机构，包括罗格斯-新不伦瑞克大学（NB）、罗格斯-纽瓦克大学、普林斯顿大学和蒙特克莱尔州立大学（MSU）。10名教职员工，其中3名来自罗格斯- nb /RWJ， 1名来自罗格斯-纽瓦克，4名来自普林斯顿，2名来自密歇根州立大学，参加了新泽西宽800 MHz核磁共振设施。获得800兆赫的核磁共振将允许全州小组实施一系列最先进的生物核磁共振实验，这些实验目前在500和600兆赫的核磁共振上是不可行的，并将提高他们在时间密集型核磁共振项目方面的生产力。新泽西州800兆赫核磁共振设施的建立将提高核磁共振研究和教育对新泽西州社区的质量和可及性。目前无法在各自机构的底层现场仪器上进行的最先进的核磁共振研究，现在将向新泽西核磁共振社区开放。此外，新泽西州的800兆赫核磁共振设施为本科生、毕业生和博士后提供了一个机会，可以与来自新泽西州其他学校的研究人员见面，接受最先进的核磁共振仪器的培训，并接触到许多不同的核磁共振研究项目。拥有800 MHz核磁共振服务于许多不同的机构，为核磁共振用户提供了一个智能环境和协作框架。“动手”核磁共振实验将由大约60名参与核磁共振研究的研究生、博士后和本科生进行。该设施成员的研究活动是在分子生物物理学，重点在以下领域：蛋白质结构测定；折叠和未折叠蛋白质的构象研究和动力学，以了解蛋白质折叠和错误折叠的基础；核酸结构及其相互作用的研究；蛋白质-蛋白质和蛋白质-核酸相互作用的核磁共振研究；小肽的设计与构象分析下一代应用的核磁共振方法开发。我们将建立的新泽西州范围内的800 MHz核磁共振设施将为新泽西州私立和公立大学的许多研究和教育项目提供基础设施，提高质量和可及性。在将这组大学聚集在一起的过程中，我们正在建立一个合作的环境，并协调来自许多不同机构的核磁共振专业知识。新泽西宽800兆赫核磁共振设施为本科生，毕业生和博士后提供了一个机会，以满足来自其他新泽西学校的研究人员，并接触到许多不同的核磁共振研究项目。拥有800 MHz核磁共振服务于许多不同的机构，为核磁共振用户提供了一个智能环境和协作框架。