Acquisition of NMR Spectrometer for Chemistry

购置化学用核磁共振波谱仪

• 批准号: 0412901
• 负责人: Claude Yoder
• 金额: $ 52.73万
• 依托单位: Franklin and Marshall College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0412901&HistoricalAwards=false
• 关键词: Acquisition; NMR; Spectrometer; Chemistry

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Franklin and Marshall College will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies on atranyl-nucleosides as transition state analogs in the study of the hammerhead ribozyme, in vivo incorporation of photocrosslinked amino acids to increase protein stability, molecular recognition using fluorescent chemsensors, the mechanism of the [1,3]carbon shift, hypercoordination in organogermanium compounds, and the structure-lattice energy relationship in lead double salts. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organometallic chemistry and biochemistry.

在主要研究仪器(MRI)计划的这一奖励下，富兰克林和马歇尔学院的化学系将获得一台400 MHz核磁共振(核磁共振)光谱仪。这台设备将使研究人员能够在锤头状核酶的研究中将atranyl-核苷作为过渡态类似物进行研究，在体内掺入光交联氨基酸以提高蛋白质的稳定性，利用荧光化学传感器进行分子识别，研究[1，3]碳移动的机制，有机锗化合物中的超配位，以及铅复盐中的结构-晶格能量关系。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机金属化学和生物化学产生影响。