CAREER: Long-Range Dipolar Fields as a Tool for Nuclear Magnetic Resonance Microscopy

职业：长程偶极场作为核磁共振显微镜的工具

• 批准号: 0545461
• 负责人: Carlos Meriles
• 金额: $ 58.7万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0545461&HistoricalAwards=false
• 关键词: CAREER; Long; Range; Dipolar; Fields

In this CAREER award, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Carlos Meriles of the City University of New York -- City College and his postdoctoral and graduate research students will develop a general strategy for high-sensitivity detection of Nuclear Magnetic Resonance (NMR) for use in micro-imaging and micro-spectroscopy of organic and biological materials. This will be achieved by detecting the change in nuclear polarization, via long-range dipolar interaction, of a hyper-polarized semiconductor tip as it interacts with a sample. Prof. Meriles will also develop a new course on imaging methods for graduate students and will further develop his science course for non-science undergraduates. Due to its low sensitivity, the spatial resolution of conventional Magnetic Resonance Imaging (MRI) is limited. Scanning microscopy techniques have much better spatial resolution than MRI, but these techniques do not have the superb chemical contrast achievable with MRI. Prof. Meriles' group hopes to develop a technique that combines strengths of both MRI and scanning microscopy so that scientists may ultimately be able to obtain meaningful MRI images of single biological cells.

在这项由化学系实验物理化学项目资助的职业奖项中，纽约市立大学市立学院的卡洛斯·梅里尔斯教授及其博士后和研究生将开发一种用于有机和生物材料的显微成像和显微光谱的高灵敏度核磁共振检测的一般策略。这将通过检测超极化半导体针尖与样品相互作用时核极化的变化，通过远程偶极相互作用实现。梅里尔斯教授还将为研究生开发一门关于成像方法的新课程，并将进一步为非理科本科生开发他的科学课程。常规磁共振成像(MRI)由于灵敏度低，空间分辨率受到限制。扫描显微镜技术具有比MRI更好的空间分辨率，但这些技术没有MRI所能实现的极好的化学对比度。梅里尔斯教授的团队希望开发一种结合核磁共振和扫描显微镜两者优点的技术，以便科学家最终能够获得有意义的单个生物细胞的核磁共振图像。