CAREER: Long-Range Dipolar Fields as a Tool for Nuclear Magnetic Resonance Microscopy

在这个由化学系实验物理化学项目资助的职业奖中，纽约城市大学-城市学院的卡洛斯·梅里尔斯教授和他的博士后和研究生将开发一种用于有机和生物材料显微成像和显微光谱学的核磁共振（NMR）高灵敏度检测的一般策略。 这将通过检测核极化的变化来实现，通过长程偶极相互作用，超极化半导体尖端，因为它与样品相互作用。 Meriles教授还将为研究生开发一门关于成像方法的新课程，并将进一步为非理科本科生开发他的理科课程。 由于其低灵敏度，常规磁共振成像（MRI）的空间分辨率有限。 扫描显微镜技术具有比MRI好得多的空间分辨率，但这些技术不具有MRI可实现的极好的化学对比度。 Meriles教授的团队希望开发一种结合MRI和扫描显微镜优势的技术，以便科学家最终能够获得单个生物细胞的有意义的MRI图像。

In this CAREER award, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Carlos Meriles of the City University of New York -- City College and his postdoctoral and graduate research students will develop a general strategy for high-sensitivity detection of Nuclear Magnetic Resonance (NMR) for use in micro-imaging and micro-spectroscopy of organic and biological materials. This will be achieved by detecting the change in nuclear polarization, via long-range dipolar interaction, of a hyper-polarized semiconductor tip as it interacts with a sample. Prof. Meriles will also develop a new course on imaging methods for graduate students and will further develop his science course for non-science undergraduates. Due to its low sensitivity, the spatial resolution of conventional Magnetic Resonance Imaging (MRI) is limited. Scanning microscopy techniques have much better spatial resolution than MRI, but these techniques do not have the superb chemical contrast achievable with MRI. Prof. Meriles' group hopes to develop a technique that combines strengths of both MRI and scanning microscopy so that scientists may ultimately be able to obtain meaningful MRI images of single biological cells.