Mapping Protein Contacts and Conformational Changes in Macromolecular Assemblies

我们现在对蛋白质的结构有了大量的了解，这些蛋白质相互作用，进行了许多控制细胞和生物体生命的化学反应，但我们才刚刚开始了解蛋白质是如何在执行许多细胞功能的大型动态分子机器中相互交流的。澳大利亚投资了昂贵的仪器，这些仪器可以与新的实验室方法结合使用，以更好地了解这些机器如何工作以及它们如何在疾病中发生故障。该项目将汇集四位具有独特专业知识和新技术的科学家，以发展对不同功能状态下大型蛋白质复合物结构变化的理解。

We now have a great deal of information about the structures of proteins that interact to do much of the chemistry that governs the lives of cells and organisms, but are just beginning to understand how proteins communicate with each other in the large, dynamic molecular machines that carry out many cellular functions. Australia has invested in expensive instrumentation that can be used in conjunction with new laboratory methods to develop better understanding of how these machines work, and how they malfunction in disease. This project will bring together four scientists with a unique combination of expertise and novel technologies to develop understanding of changes in structure of a large protein complex in different functional states.