Mapping Protein Contacts and Conformational Changes in Macromolecular Assemblies

绘制大分子组装体中的蛋白质接触和构象变化图

• 批准号: DP0984797
• 负责人: Prof Nicholas Dixon
• 金额: $ 63.42万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-02 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984797
• 关键词: Mapping; Protein; Contacts; Conformational; Changes

We now have a great deal of information about the structures of proteins that interact to do much of the chemistry that governs the lives of cells and organisms, but are just beginning to understand how proteins communicate with each other in the large, dynamic molecular machines that carry out many cellular functions. Australia has invested in expensive instrumentation that can be used in conjunction with new laboratory methods to develop better understanding of how these machines work, and how they malfunction in disease. This project will bring together four scientists with a unique combination of expertise and novel technologies to develop understanding of changes in structure of a large protein complex in different functional states.

我们现在有了大量关于蛋白质结构的信息，这些蛋白质相互作用，产生了许多控制细胞和生物体生命的化学作用，但我们才刚刚开始了解蛋白质如何在执行许多细胞功能的大型动态分子机器中相互交流。澳大利亚投资了昂贵的仪器，可以与新的实验室方法结合使用，以更好地了解这些机器如何工作，以及它们如何在疾病中发生故障。该项目将汇集四位科学家，他们将专业知识和新技术结合在一起，以了解不同功能状态下大型蛋白质复合物结构的变化。