Enabling Technologies for Structural Genomics

结构基因组学的支持技术

• 批准号: DP0342435
• 负责人: Prof Nicholas Dixon
• 金额: $ 30.37万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0342435
• 关键词: Enabling; Technologies; Structural; Genomics

New technologies will be developed to save time, money and effort in rapid preparation of protein samples for structural genomics. Systems will be devised for preparing sufficient isotope-labelled proteins for nuclear magnetic resonance spectroscopy without using living organisms, for efficiently identifying points at which proteins can be broken into smaller fragments with the right properties, and for joining the ends of proteins and peptides together to make them much more stable. This combination of technologies are widely applicable to current problems in protein chemistry, molecular biology, functional genomics and the medical sciences.

将开发新技术来节省时间、金钱和精力，快速制备结构基因组学的蛋白质样本。将设计系统来制备足够的同位素标记的蛋白质用于核磁共振光谱，而不使用活的生物体，有效地识别蛋白质可以被分解成具有正确特性的较小片段的点，并将蛋白质和肽的末端连接在一起，使它们更加稳定。这种技术的组合广泛适用于蛋白质化学、分子生物学、功能基因组学和医学科学中的当前问题。