Structures to Solve Conflicts of DNA Replication and RNA Transcription

解决 DNA 复制和 RNA 转录冲突的结构

• 批准号: DP210100365
• 负责人: Prof Nicholas Dixon
• 金额: $ 48.61万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-22 至 2024-02-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100365
• 关键词: Structures; Solve; Conflicts; DNA; Replication

This project aims to understand how new DNA is made so quickly and without mistakes in cells that are about to divide, in spite of competition from other processes happening at the same time on the DNA that should stop or interfere with it, such as the synthesis of RNA. The project expects to use the latest available methods to uncover what the microscopic natural machines that make DNA and RNA look like, and how they compete with each other for access to DNA. Potential outcomes include the identification of processes that can be compromised by small molecules that may be developed into new antibiotics. This would be of great benefit - new antibiotics are urgently needed as one approach to countering the threat of antimicrobial resistance.

该项目旨在了解如何在即将分裂的细胞中如此快速地制造出新的 DNA，并且不会出现错误，尽管同时发生的其他过程会阻止或干扰 DNA，例如 RNA 的合成。该项目期望使用最新的可用方法来揭示制造 DNA 和 RNA 的微观自然机器是什么样子，以及它们如何相互竞争获取 DNA。潜在的结果包括识别可能被小分子破坏的过程，这些小分子可能被开发成新的抗生素。这将带来巨大的好处——迫切需要新的抗生素作为应对抗菌素耐药性威胁的一种方法。