Facility for the Analysis of Biomacromolecular Interactions

生物大分子相互作用分析设备

• 批准号: LE0560751
• 负责人: Prof Nicholas Dixon
• 金额: $ 28.84万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE0560751
• 关键词: Facility; Analysis; Biomacromolecular; Interactions

A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available only in small quantities, and small, drug related molecules (by microcalorimetry and dual polarization interferometry), and (ii) provide equipment necessary for sample characterization and purification prior to quantitative measurements (CD spectroscopy, and FPLC equipment).

需要一个分析生物大分子及其与配体分子相互作用的设施，以支持三所不同大学在高度优先领域的大量研究项目，包括衰老机制、药物开发和生物/纳米技术。该仪器将(I)定量测量生物和化学大分子之间的结合亲和力，这些大分子只有少量可用，以及与药物相关的小分子(通过微量热法和双极化干涉法)，以及(Ii)在定量测量之前提供样品表征和纯化所需的设备(CD光谱和FPLC设备)。