Functional Dissection of the Bacterial Replisome

细菌复制体的功能解剖

• 批准号: DP0877658
• 负责人: Prof Nicholas Dixon
• 金额: $ 77.27万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-05-06 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877658
• 关键词: Functional; Dissection; Bacterial; Replisome

We now have the complete sequences of genes in humans and many other organisms, but we know much less about how the protein products of the genes communicate with each other to create and grow cells. Australia has recently invested heavily in state-of-the-art instruments that can be used to tackle these problems. This project will involve close interaction of four laboratories to use new instruments to determine how a large assembly of proteins interact in a biological machine that makes DNA. This process occurs in similar ways in all organisms, and is essential for life. Understanding how DNA is made will help scientists to develop new antibacterial drugs, and learn how to make practical use of molecular machines that imitate biology.

我们现在拥有人类和许多其他生物体的完整基因序列，但我们对基因的蛋白质产物如何相互交流以创造和生长细胞知之甚少。澳大利亚最近在可用于解决这些问题的最先进手段方面进行了大量投资。该项目将涉及四个实验室的密切互动，使用新仪器来确定蛋白质的大集合如何在制造DNA的生物机器中相互作用。这个过程在所有生物体中以类似的方式发生，并且是生命所必需的。了解DNA是如何制造的将有助于科学家开发新的抗菌药物，并学习如何实际使用模仿生物学的分子机器。