Subunit Contacts in a Replicative DNA Polymerase: A New Paradigm for Protein-Protein Interactions?
Subunit Contacts in a Replicative DNA Polymerase: A New Paradigm for Protein-Protein Interactions?
批准号:
LC0348576
负责人:
Prof Nicholas Dixon
金额:
$13.49万
依托单位国家:
澳大利亚
项目类别:
Linkage - CSIRO
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-10-09 至 2006-10-08
中文摘要
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英文摘要
The bacterial DNA polymerase III is a 15-subunit protein that acts as an extraordinary molecular machine to copy both strands of chromosomal DNA at the same time, making DNA at the rate of 1000 base pairs each second without ever falling off the chromosome or making mistakes. This project aims to understand the way its subunits iteract, such that they can form stable complexes that are nevertheless flexible enough to accomplish DNA synthesis. There are applications of this knowledge to discovery of new antibacterial agents and in design of new protein machines.
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Structures to Solve Conflicts of DNA Replication and RNA Transcription
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批准号:DP210100365
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项目类别:Discovery Projects
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资助金额:$48.61万
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财政年份:2021
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负责人:Prof Nicholas Dixon
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依托单位:
Molecular Interactions with an antibiotic target in DNA replication
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批准号:DP180100805
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项目类别:Discovery Projects
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资助金额:$37.41万
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财政年份:2018
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负责人:Prof Nicholas Dixon
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依托单位:
Mapping Protein Contacts and Conformational Changes in Macromolecular Assemblies
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批准号:DP0984797
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项目类别:Discovery Projects
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资助金额:$63.42万
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财政年份:2009
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负责人:Prof Nicholas Dixon
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依托单位:
Regional Facility for Real Time Analysis of Molecular Interactions
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批准号:LE0989077
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$15.04万
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财政年份:2009
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负责人:Prof Nicholas Dixon
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依托单位:
Functional Dissection of the Bacterial Replisome
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批准号:DP0877658
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项目类别:Discovery Projects
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资助金额:$77.27万
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财政年份:2008
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负责人:Prof Nicholas Dixon
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依托单位:
New Techniques for Structural Biology and Directed Molecular Evolution
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批准号:LP0882009
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项目类别:Linkage Projects
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资助金额:$6.26万
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财政年份:2008
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负责人:Prof Nicholas Dixon
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依托单位:
Molecular Interactions in the Eubacterial Replisome: A Paradigm for Study of Dynamic Macromolecular Machines
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批准号:DP0663293
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项目类别:Discovery Projects
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资助金额:$25.24万
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财政年份:2006
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负责人:Prof Nicholas Dixon
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依托单位:
Single Molecule Studies of Replisomal Function
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批准号:LX0668812
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项目类别:Linkage - International
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资助金额:$1.39万
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财政年份:2006
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负责人:Prof Nicholas Dixon
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依托单位:
Facility for the Analysis of Biomacromolecular Interactions
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批准号:LE0560751
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$28.84万
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财政年份:2005
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负责人:Prof Nicholas Dixon
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依托单位:
New Methods for Directed Molecular Evolution of Novel Protein Functions
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批准号:LP0454089
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项目类别:Linkage Projects
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资助金额:$8.55万
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财政年份:2004
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负责人:Prof Nicholas Dixon
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依托单位:
Enabling Technologies for Structural Genomics
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批准号:DP0342435
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项目类别:Discovery Projects
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资助金额:$30.37万
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财政年份:2003
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负责人:Prof Nicholas Dixon
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依托单位:
Structures and Functions of Bacterial Replisomal Proteins
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批准号:DP0208428
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项目类别:Discovery Projects
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资助金额:$12.56万
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财政年份:2002
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负责人:Prof Nicholas Dixon
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依托单位:
海外基金