Molecular Interactions in the Eubacterial Replisome: A Paradigm for Study of Dynamic Macromolecular Machines

许多病原菌对常用抗生素产生了抗药性，迫切需要新的药物来杀死它们。在分裂成两个新的细胞之前复制它们的染色体是细菌生存所必需的，所以DNA合成是开发新抗生素的一个很好的过程。这个项目将使用澳大利亚和海外几个实验室提供的最先进的设备，以发展对复制DNA的分子机器如何工作的新理解。这一知识可能会带来新的药物，并将为我们提供关于细胞机器如何工作的新信息。

Many pathogenic bacteria have developed resistance to antibiotics in common use, and new drugs are urgently required to kill them. Copying of their chromosomes before they divide into two new cells is essential for bacteria to live, so DNA synthesis is a good process to target for development of new antibiotics. This project will use state-of-the-art equipment available in several laboratories in Australia and overseas to develop new understanding of how the molecular machine that copies DNA works. This k nowledge could lead to new drugs, and will give us new information about how cellular machines function.