Molecular Interactions in the Eubacterial Replisome: A Paradigm for Study of Dynamic Macromolecular Machines

真细菌复制体中的分子相互作用：动态大分子机器研究的范式

• 批准号: DP0663293
• 负责人: Prof Nicholas Dixon
• 金额: $ 25.24万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663293
• 关键词: Molecular; Interactions; Eubacterial; Replisome; Paradigm

Many pathogenic bacteria have developed resistance to antibiotics in common use, and new drugs are urgently required to kill them. Copying of their chromosomes before they divide into two new cells is essential for bacteria to live, so DNA synthesis is a good process to target for development of new antibiotics. This project will use state-of-the-art equipment available in several laboratories in Australia and overseas to develop new understanding of how the molecular machine that copies DNA works. This k nowledge could lead to new drugs, and will give us new information about how cellular machines function.

许多病原菌对常用抗生素产生了耐药性，迫切需要新药来杀灭它们。在它们分裂成两个新细胞之前，它们的染色体分裂是细菌生存所必需的，因此DNA合成是开发新抗生素的一个很好的过程。该项目将使用澳大利亚和海外几个实验室的最先进设备，对复制DNA的分子机器如何工作进行新的理解。这种知识可能会导致新的药物，并将为我们提供有关细胞机器如何运作的新信息。