MRI: Acquisition of an 800 MHz NMR Spectrometer

该奖项是为了获得一个高场NMR（核磁共振）光谱仪与冷冻探针。 16名研究人员将使用该仪器进行以下研究：生物大分子结构和动力学的溶液状态表征，有机化合物的结构表征（天然产物和合成有机物;许多aremass-limited），代谢物研究和新NMR方法的开发。这项研究将对蛋白质结构和动力学、酶功能、RNA-肽相互作用、分子支架和组装、污染的影响、代谢物的表征和新型生物合成产生新的见解。新仪器将在大学的教育和专业培训中发挥重要作用。研究人员来自校园的七个部门，该仪器将使200多名研究生和本科生以及博士后研究人员的用户群能够获得比现在更大的色散和灵敏度的高场光谱。现有的低场仪器将被解放，用于更多的日常工作，允许合理划分NMR时间在所有可用的仪器用于研究和教学的研究生和本科生。NMR是在各个部门提供的许多校园课程的特色组成部分，有几门课程有一个实验室组件与NMR光谱仪的动手操作。教师利用拟议的核磁共振光谱仪参加完善的少数民族推广计划，如MURPPS计划，NSF青年学者和ACS项目种子。

This award is for the acquisition of a high-field NMR (Nuclear Magnetic Resonance) spectrometer with cryoprobe. Sixteen investigators will use this instrument for research on: solution state characterization of the structure and dynamics of biological macromolecules, structural characterization of organic compounds (both natural products and synthesized organics; many aremass-limited), metabolite studies, and development of new NMR methods. This research will produce new insights into protein structure and dynamics, enzyme function, RNA-peptide interactions, molecular scaffolds and assemblies, effects of pollution, characterization of metabolites, and novel biosynthesis.The new instrument will play a major role in education and professional training at the university. The investigators are from seven departments on campus, and the instrument will enable a user base of over 200 graduate and undergraduate students and post-doctoral researchers to obtain high field spectra with greater dispersion and sensitivity than is now possible. Existing lower field instruments will be liberated for more routine work, allowing rational partitioning of NMR time on all available instruments for use in research and teaching of graduates and undergraduates. NMR is a featured component in numerous campus courses offered in a variety of departments, with several courses having a lab component with hands-on operation of NMR spectrometers. Faculty utilizing the proposed NMR spectrometer participate in well-established minority outreach programs such as the MURPPS program, NSF Young Scholars and ACS Project SEED.