MRI: Acquisition of an 800 MHz NMR Spectrometer

该合同是为获得一台带有低温探头的高场核磁共振(核磁共振)光谱仪而授予的。16名研究人员将使用这台仪器进行以下研究：生物大分子结构和动力学的溶液状态表征、有机化合物(包括天然产物和合成有机物；许多是质量受限的)的结构表征、代谢物研究以及新核磁共振方法的开发。这项研究将对蛋白质结构和动力学、酶功能、RNA-肽相互作用、分子支架和组装、污染的影响、代谢物的表征和新的生物合成产生新的见解。新仪器将在大学的教育和专业培训中发挥重要作用。研究人员来自校园内的七个系，该仪器将使200多名研究生、本科生和博士后研究人员的用户群能够获得比现在更大的色散和灵敏度的高场光谱。现有的低场仪器将被解放出来，用于更常规的工作，允许在所有可用仪器上合理分配核磁共振时间，用于研究生和本科生的研究和教学。核磁共振是在不同系开设的许多校园课程中的一个特色组件，有几门课程有一个实验室组件，上面有核磁共振光谱仪的实际操作。使用建议的核磁共振光谱仪的教员参与了著名的少数族裔外联计划，如MURPPS计划、NSF青年学者和ACS项目种子。

This award is for the acquisition of a high-field NMR (Nuclear Magnetic Resonance) spectrometer with cryoprobe. Sixteen investigators will use this instrument for research on: solution state characterization of the structure and dynamics of biological macromolecules, structural characterization of organic compounds (both natural products and synthesized organics; many aremass-limited), metabolite studies, and development of new NMR methods. This research will produce new insights into protein structure and dynamics, enzyme function, RNA-peptide interactions, molecular scaffolds and assemblies, effects of pollution, characterization of metabolites, and novel biosynthesis.The new instrument will play a major role in education and professional training at the university. The investigators are from seven departments on campus, and the instrument will enable a user base of over 200 graduate and undergraduate students and post-doctoral researchers to obtain high field spectra with greater dispersion and sensitivity than is now possible. Existing lower field instruments will be liberated for more routine work, allowing rational partitioning of NMR time on all available instruments for use in research and teaching of graduates and undergraduates. NMR is a featured component in numerous campus courses offered in a variety of departments, with several courses having a lab component with hands-on operation of NMR spectrometers. Faculty utilizing the proposed NMR spectrometer participate in well-established minority outreach programs such as the MURPPS program, NSF Young Scholars and ACS Project SEED.