MRI: Acquisition of an 800 MHz NMR Spectrometer

MRI：购买 800 MHz NMR 波谱仪

• 批准号: 0722538
• 负责人: Gary Smith
• 金额: $ 160万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0722538&HistoricalAwards=false
• 关键词: MRI; Acquisition; 800; MHz; NMR

This award is for the acquisition of a high-field NMR (Nuclear Magnetic Resonance) spectrometer with cryoprobe. Sixteen investigators will use this instrument for research on: solution state characterization of the structure and dynamics of biological macromolecules, structural characterization of organic compounds (both natural products and synthesized organics; many aremass-limited), metabolite studies, and development of new NMR methods. This research will produce new insights into protein structure and dynamics, enzyme function, RNA-peptide interactions, molecular scaffolds and assemblies, effects of pollution, characterization of metabolites, and novel biosynthesis.The new instrument will play a major role in education and professional training at the university. The investigators are from seven departments on campus, and the instrument will enable a user base of over 200 graduate and undergraduate students and post-doctoral researchers to obtain high field spectra with greater dispersion and sensitivity than is now possible. Existing lower field instruments will be liberated for more routine work, allowing rational partitioning of NMR time on all available instruments for use in research and teaching of graduates and undergraduates. NMR is a featured component in numerous campus courses offered in a variety of departments, with several courses having a lab component with hands-on operation of NMR spectrometers. Faculty utilizing the proposed NMR spectrometer participate in well-established minority outreach programs such as the MURPPS program, NSF Young Scholars and ACS Project SEED.

该合同是为了获得一台带冷冻探针的高场核磁共振光谱仪。16名研究人员将使用该仪器进行以下研究：生物大分子结构和动力学的溶液状态表征、有机化合物（天然产物和合成有机物；许多是质量有限的）的结构表征、代谢物研究和新核磁共振方法的开发。这项研究将对蛋白质结构和动力学、酶功能、rna -肽相互作用、分子支架和组装、污染的影响、代谢物的表征和新的生物合成产生新的见解。这台新仪器将在该大学的教育和专业培训中发挥重要作用。研究人员来自校园的七个系，该仪器将使200多名研究生和本科生以及博士后研究人员能够获得比现在更大的色散和灵敏度的高场光谱。现有的下层野外仪器将被解放出来，用于更多的日常工作，允许在所有可用仪器上合理分配核磁共振时间，用于研究生和本科生的研究和教学。核磁共振是在各种部门提供的众多校园课程的特色组成部分，有几个课程有一个实验室组件与核磁共振光谱仪的动手操作。利用核磁共振谱仪的教师参与了完善的少数民族外展项目，如MURPPS项目、NSF青年学者项目和ACS SEED项目。