MRI: Acquisition of an LC-MS/MS Mass Spectrometer by Cleveland State University

克利夫兰州立大学化学系将获得重大研究仪器(MRI)项目颁发的这一奖项，从而获得一套三重四极/线性离子陷阱液相色谱质谱计系统(LC MS/MS)。该仪器将促进广泛的科学和工程领域的研究，包括：分析化学、有机化学、临床化学、药理学、法医化学、环境科学、生物化学、分子生物学、绿色和可再生能源、纳米科学、工程学等。这些项目包括：i)阐明抗药性的分子机制；ii)用于药物输送的生物材料开发；iii)药物的事前和死后法医分析；iv)纳米颗粒燃料电池；v)高效生物燃料生产；vi)肝脏中脂类的代谢研究：生物学和分析方面；vii)与质谱仪连接的新分离技术；viii)阐明植物砷解毒机制的蛋白质组学研究；和ix)促进学习的本科生研究经验：在分析和药物化学领域的研究经验促进学习(REEL)计划中使用质谱仪(MS)来鉴定样品的化学成分，并通过测量样品中的分子组成的质量来确定其纯度，样品被电离并由质谱仪检测。串联质谱计系统是两个串联的质谱仪，以更好地识别研究中的成分。层析是一种分离技术，它先于质谱分析。它将混合物分离成几种化学成分，然后由质谱仪进行分析和鉴定。这些是一些最广泛使用的分析技术，用于识别和量化样品的化学成分。LC-MS/MS将改善本科生和研究生的教育和培训。此次收购涉及克利夫兰州立大学(CSU)化学系、生物、地质和环境科学系、电气与计算机工程系和化学与生物医学工程系的教职员工和学生，以及凯霍加县验尸官办公室、俄亥俄大学东北医学院、阿克伦大学、凯斯西储大学的研究人员和凯霍加社区学院(CCC)的学生。这一工具将促进这些部门和机构之间的发展和跨学科研究，这将成为CSU、克利夫兰地区机构和俄亥俄州东北部社区在研究和教育方面发展新想法的催化剂。

With this award from the Major Research Instrumentation (MRI) program, the Chemistry Department at Cleveland State University will acquire a triple quadrupole/linear ion trap liquid chromatograph mass spectrometer system (LC MS/MS). This instrument will promote research in a wide range of scientific and engineering fields, including: analytical chemistry, organic chemistry, clinical chemistry, pharmacology, forensic chemistry, environmental sciences, biochemistry, molecular biology, green and renewable energy, nano-science, engineering, and others. The projects include studies on: I) Elucidating molecular mechanisms of drug resistance; II) Biomaterial development for drug delivery; III) Ante- and post-mortem forensic analysis of drugs; IV) Nano-particle fuel cells; V) Efficient bio-fuel production; VI) Metabolomic studies of lipids in the liver: biological and analytical aspects; VII) A novel separation technology interfaced to mass spectrometry; VIII) Proteomic studies to elucidate plant arsenic detoxification mechanisms; and IX) Undergraduate research experiences to enhance learning: Use in the Research Experiences to Enhance Learning (REEL) Program in Analytical and Pharmaceutical ChemistryMass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. A tandem mass spectrometer system is two mass filters in series to better identify the constituents under study. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed and identified by the mass spectrometer. These are some of the most widely used analytical techniques used to identify and quantify the chemical composition of a sample. The LC-MS/MS would improve the education and training of undergraduate and graduate students. This acquisition involves faculty and students from the Department of Chemistry, the Department of Biological, Geological and Environmental Sciences, the Department of Electrical & Computer Engineering, and the Department of Chemical and Biomedical Engineering at Cleveland State University (CSU), as well as researchers from Cuyahoga County Coroner's Office, Northeastern Ohio Universities College of Medicine, University of Akron , Case Western Reserve University, and students from Cuyahoga Community College (CCC). This instrument will promote the growth and interdisciplinary research between these departments, and institutions, that will act as a catalyst for the development of new ideas in research and education within CSU, Cleveland area institutions and the Northeast Ohio community