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MRI: Acquisition of Liquid Chromatograph/Mass Spectrometer for Research and Education

MRI：购买液相色谱仪/质谱仪用于研究和教育

基本信息

批准号：
1726931
负责人：
Victor Ryzhov
金额：
$ 25.36万
依托单位：
Northern Illinois University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726931&HistoricalAwards=false
关键词：
MRI Acquisition Liquid Chromatograph Mass

项目摘要

This award is supported by the Major Research Instrumentation (MRI) and Chemical Research Instrumentation and Facilities (CRIF) Programs. Professor Victor Ryzhov from Northern Illinois University and colleagues Ralph Wheeler, Elizabeth Gaillard, Melissa Lenczewski and James Horn are acquiring a liquid chromatograph, ion-trap, time-of-flight mass spectrometer (LC-IT-TOF-MS). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized and measured. This highly sensitive technique allows the detection and determination of the structures of molecules in a complex mixture. In an instrument with an ion trap, a combination of magnetic and electric fields capture the charged particles. With the TOF capabilities the sample is finely vaporized into a spray, then the ions are accelerated by an electric field to allow further characterization. The liquid chromatograph component allows separation of mixtures before the components are analyzed. This acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse students in research and training using this modern analytical technique. The instrument serves students and researchers from various undergraduate colleges such as Harper, Rock Valley and Knox Colleges as well as Olivet Nazarene University.This mass spectrometer enhances research and education at all levels. The tool benefits researchers studying engineering proteins and age-related processes that could be relevant to the eye. The instrumentation is also used for studies that may be relevant for understanding proteomics, developing delivery agents for boron neutron capture, and discovering enzyme inhibitors. The mass spectrometer also enables research for new synthetic methods for complex organic synthesis; These methods that may be relevant for drug discovery studies. Finally, the instrumentation is used to study peptide photodegradation and water pollutants.

该奖项由主要研究仪器（MRI）和化学研究仪器和设施（CRIF）项目支持。北伊利诺伊大学的Victor Ryzhov教授和他的同事Ralph Wheeler、Elizabeth Gaillard、Melissa Lenczewski和James Horn正在购买一台液相色谱仪、离子阱、飞行时间质谱仪（LC-IT-TOF-MS）。一般来说，质谱（MS）是用于鉴定和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离并测量。这种高度灵敏的技术可以检测和确定复杂混合物中的分子结构。在带有离子阱的仪器中，磁场和电场的结合可以捕获带电粒子。有了TOF功能，样品被精细地汽化成喷雾，然后离子被电场加速，以允许进一步表征。液相色谱仪组件允许在组分分析之前分离混合物。此次收购加强了大学和地区的研究基础设施。该仪器通过让不同的学生参与使用这种现代分析技术的研究和培训，扩大了参与范围。该仪器服务于各种本科学院的学生和研究人员，如哈珀，岩石谷和诺克斯学院以及橄榄拿撒勒大学。这种质谱仪加强了各级的研究和教育。该工具有利于研究工程蛋白和可能与眼睛相关的年龄相关过程的研究人员。该仪器还用于研究可能与理解蛋白质组学，开发硼中子捕获的递送剂和发现酶抑制剂相关的研究。质谱仪还为复杂有机合成的新合成方法的研究提供了可能；这些方法可能与药物发现研究相关。最后，利用该仪器对多肽光降解和水污染物进行了研究。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Superelectrophilic nazarov cyclizations with N-heterocycles

N-杂环的超亲电纳扎罗夫环化

DOI：
10.1016/j.tet.2020.131644
发表时间：
2020
期刊：
Tetrahedron
影响因子：
2.1
作者：
Vuong, Hien;Amadou, Harouna;Stentzel, Michael R.;Klumpp, Douglas A.
通讯作者：
Klumpp, Douglas A.

A Two-Step Catalytic Cycle for the Acceptorless Dehydrogenation of Ethane by Group 10 Metal Complexes: Role of the Metal in Reactivity and Selectivity

DOI：
10.1021/acs.organomet.0c00598
发表时间：
2020-11
期刊：
Organometallics
影响因子：
2.8
作者：
K. Parker;Geethika K. Weragoda;A. Canty;Anastasios Polyzos;V. Ryzhov;R. O'hair
通讯作者：
K. Parker;Geethika K. Weragoda;A. Canty;Anastasios Polyzos;V. Ryzhov;R. O'hair

Synthesis of Menthol Glycinates and Their Potential as Cooling Agents

DOI：
10.1021/acsomega.9b03624
发表时间：
2020-02
期刊：
ACS Omega
影响因子：
4.1
作者：
D. Klumpp;R. Sobel;S. Kokkinidou;Brian Osei-Badu;Zachary Liveris;Rachel A. Klumpp;Michael R. Stentzel
通讯作者：
D. Klumpp;R. Sobel;S. Kokkinidou;Brian Osei-Badu;Zachary Liveris;Rachel A. Klumpp;Michael R. Stentzel

Gas‐Phase Models for the Nickel‐ and Palladium‐Catalyzed Deoxygenation of Fatty Acids

DOI：
10.1002/cctc.202000908
发表时间：
2020-09
期刊：
ChemCatChem
影响因子：
4.5
作者：
K. Parker;Geethika K. Weragoda;V. Pho;A. Canty;Anastasios Polyzos;R. O'hair;V. Ryzhov
通讯作者：
K. Parker;Geethika K. Weragoda;V. Pho;A. Canty;Anastasios Polyzos;R. O'hair;V. Ryzhov