New Reactions and Strategies in Synthesis

化学系的化学合成项目支持哈佛大学Myers教授的研究小组开发在实验室中简单构建复杂分子的新方法。本研究主要集中在三个方面：1)不对称合成新助剂的范围和用途的研究；2)取代四氢异喹啉和异喹啉类化合物合成新方法的发展；3)开发可储存试剂，用于在水介质中标记烯烃。将研究形成具有绝对立体化学控制的碳-碳和碳-氮键的新转化。提出的合成产物在制药工业中具有很大的潜在应用前景，并可能为金属催化转化提供新的配体平台。合成化学中新变化的发现不仅具有实际应用价值，而且具有内在的智力价值。通常，合成有机化学中的新方法会导致对基本反应机制的新理解或对化学反应性的全新看法的发展，并启动进一步发现和见解的循环。这项研究的设计具有实用性，因此，可以想象，这项工作的创新可能会在工业上得到应用，比如精细化学或制药产品的合成。合成有机化学的发展给社会带来了巨大的利益。化学合成领域的基础研究是必要的，它为所有领域的科学家提供了快速、可靠地构建新分子结构所需的工具，用于任何可能的目的。潜在的应用包括发现新的药剂、农产品和材料，以及开发更有效和/或对环境有利的工业过程。这项研究还将为研究生提供培训，为他们在学术界和化学工业的职业生涯做好准备。

The Chemical Synthesis Program of the Division of Chemistry supports the research group of Professor Myers of Harvard University to develop new methods for the facile construction of complex molecules in the laboratory. This research focuses on three areas: 1) the investigation of scope and utility of a new auxiliary for asymmetric synthesis; 2) the development of new methods for the synthesis of substituted tetrahydroisoquinolines and isoquinolines; and 3) the development of storable reagents for alkene labeling in aqueous media. New transformations that form carbon-carbon and carbon-nitrogen bonds with absolute stereo-chemical control will be investigated. The products proposed for synthesis have great promise for potential applications in the pharmaceutical industry and may provide new ligand platforms for metal-catalyzed transformations. The discovery of new transformations in synthetic chemistry has inherent intellectual merit, as well as practical application. Frequently, new methods in synthetic organic chemistry lead to new understanding of basic reaction mechanisms or to the development of completely new views of chemical reactivity, and initiate cycles of further discovery and insight. The research is by design of practical nature, thus, it is conceivable that innovations from the work might find industrial application, such as in fine-chemical or pharmaceutical product synthesis. Developments in synthetic organic chemistry have tremendous benefit to society. Basic research in the field of chemical synthesis is necessary to provide scientists from all areas the tools that they need to rapidly and reliably construct new molecular structures, for any conceivable purpose. Potential applications include the discovery of new pharmaceutical agents, agricultural products, and materials, as well as the development of more efficient and/or environmentally beneficial industrial processes. This research will also provide training for graduate students, preparing them for careers in academia and chemical industries.