New Reactions and Strategies in Synthesis

合成中的新反应和策略

• 批准号: 1152205
• 负责人: Andrew Myers
• 金额: $ 50.94万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152205&HistoricalAwards=false
• 关键词: New; Reactions; Strategies; Synthesis

The Chemical Synthesis Program of the Division of Chemistry supports the research group of Professor Myers of Harvard University to develop new methods for the facile construction of complex molecules in the laboratory. This research focuses on three areas: 1) the investigation of scope and utility of a new auxiliary for asymmetric synthesis; 2) the development of new methods for the synthesis of substituted tetrahydroisoquinolines and isoquinolines; and 3) the development of storable reagents for alkene labeling in aqueous media. New transformations that form carbon-carbon and carbon-nitrogen bonds with absolute stereo-chemical control will be investigated. The products proposed for synthesis have great promise for potential applications in the pharmaceutical industry and may provide new ligand platforms for metal-catalyzed transformations. The discovery of new transformations in synthetic chemistry has inherent intellectual merit, as well as practical application. Frequently, new methods in synthetic organic chemistry lead to new understanding of basic reaction mechanisms or to the development of completely new views of chemical reactivity, and initiate cycles of further discovery and insight. The research is by design of practical nature, thus, it is conceivable that innovations from the work might find industrial application, such as in fine-chemical or pharmaceutical product synthesis. Developments in synthetic organic chemistry have tremendous benefit to society. Basic research in the field of chemical synthesis is necessary to provide scientists from all areas the tools that they need to rapidly and reliably construct new molecular structures, for any conceivable purpose. Potential applications include the discovery of new pharmaceutical agents, agricultural products, and materials, as well as the development of more efficient and/or environmentally beneficial industrial processes. This research will also provide training for graduate students, preparing them for careers in academia and chemical industries.

化学系的化学合成项目支持哈佛大学迈尔斯教授的研究小组开发在实验室中轻松构建复杂分子的新方法。 本研究集中在三个方面：1）一种新的不对称合成助剂的范围和效用的调查; 2）取代的四氢异喹啉和异喹啉的合成新方法的发展;和3）在水介质中用于烯烃标记的可储存试剂的发展。 将研究形成具有绝对立体化学控制的碳-碳和碳-氮键的新的转化。 所提出的合成产物在制药工业中具有很大的潜在应用前景，并可能为金属催化转化提供新的配体平台。 在合成化学中发现新的转变具有内在的知识价值和实际应用价值。通常，有机合成化学中的新方法导致对基本反应机理的新理解或对化学反应性的全新观点的发展，并启动进一步发现和洞察的循环。这项研究是通过实际性质的设计，因此，可以想象，从工作中的创新可能会发现工业应用，如精细化学品或医药产品合成。合成有机化学的发展对社会有巨大的好处。 化学合成领域的基础研究对于为所有领域的科学家提供快速可靠地构建新分子结构所需的工具是必要的。 潜在的应用包括发现新的药剂、农产品和材料，以及开发更高效和/或对环境有益的工业工艺。 这项研究还将为研究生提供培训，为他们在学术界和化学工业的职业生涯做好准备。