New Reactions and Strategies in Synthesis

合成中的新反应和策略

• 批准号: 0749566
• 负责人: Andrew Myers
• 金额: $ 51万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749566&HistoricalAwards=false
• 关键词: New; Reactions; Strategies; Synthesis

The project focuses on the development of new methods and new strategies for the facile construction of complex molecules in the laboratory. The research is by design of practical nature, thus, it is conceivable that innovations from the work might find industrial applications, such as in fine-chemical or pharmaceutical product synthesis. A number of new transformations that form carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds with absolute stereo-chemical control will be investigated. Molecular complexity will be developed rapidly and in ways that are subject to prediction. The complex products of the transformations hold great promise to function as useful new building blocks in chemical synthesis, with potential applications in many different areas of scientific and commercial enterprise.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Andrew G. Myers in the Department of Chemistry and Chemical Biology at Harvard University. Dr. Myers will focus his work on developing synthetic methodology that can be applied to complex synthetic problems. The broader impact of the work is in the areas of pharmaceutical, agricultural and materials chemistry. Further, the project presents an excellent setting for the training of graduate students.

该项目的重点是开发新方法和新策略，以便在实验室中轻松构建复杂分子。 这项研究是通过设计的实用性，因此，可以想象，从工作中的创新可能会发现工业应用，如在精细化学品或医药产品合成。 一些新的转变，形成碳-碳，碳-氧，和碳-氮键与绝对立体化学控制将被调查。 分子的复杂性将以可预测的方式迅速发展。 这些转化的复杂产物很有希望成为化学合成中有用的新结构单元，在科学和商业企业的许多不同领域具有潜在的应用前景。有了这个奖项，有机和大分子化学计划将支持Andrew G.迈尔斯在哈佛大学化学和化学生物学系。 Myers博士将专注于开发可应用于复杂合成问题的合成方法。 这项工作在制药、农业和材料化学领域产生了更广泛的影响。 此外，该项目为研究生的培训提供了一个极好的环境。