Scalable Nanomanufacturing and Supra-Assembly of Virus-Hybrid Janus Bionanoparticles

可扩展的纳米制造和病毒混合 Janus 生物纳米粒子的超组装

• 批准号: 1333651
• 负责人: Nicole Steinmetz
• 金额: $ 42.43万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1333651&HistoricalAwards=false
• 关键词: Scalable; Nanomanufacturing; Supra; Assembly; Virus

This grant provides funding for scaled-up nanomanufacturing and assembly of virus-based Janus bio-nanoparticles including higher-order structures. The Janus term refers to the Roman god of beginnings and transitions, depicted with two faces. As dual-faced nano-objects, Janus-type nanomaterials offer a higher degree of functionality and tunability of properties compared to most traditional nanoparticles. They also have unique self-assembly properties, allowing new phases to form and phase transitions to occur that were not previously observed. Research under this program is focused on devising scalable and in-solution synthetic methods for the production of these bio-nanoparticle assemblies with high yields, and involving fewer synthetic and purification steps, while maintaining high-precision nanostructuring and scalable manufacturing. Specifically, plant virus-based nanoparticles will be produced through genetic engineering and scalable molecular farming in plants. Sphere- and tube-like bio-nanoparticles will be applied in various geometries for solution-based chemical and colloidal synthesis. Chemical functionalization will be carried out in situ, minimizing yield-limiting purification procedures. The methods and materials produced under this award will provide a new avenue towards scalable nanomanufacturing of Janus-based nanoparticles and their higher-ordered structures. Based on the broad applicability of such materials in areas of medicine, materials, and energy, devising methods for efficient nanomanufacturing is expected to have wide-ranging applications and impact on commercialization. For example, the proposed Janus-type materials, when functionalized with appropriate ligands or ions, have possible applications in healthcare, sensors, display optics, energy conversion, and data storage devices. These materials and devices can contribute towards enhanced quality of life, sustainability, and technological competitiveness.

这笔赠款为基于病毒的Janus生物纳米颗粒（包括高阶结构）的规模化纳米制造和组装提供资金。雅努斯一词指的是罗马的开始和过渡之神，有两张脸。作为双面纳米物体，Janus型纳米材料与大多数传统纳米颗粒相比提供了更高程度的功能性和性能可调性。它们还具有独特的自组装特性，允许形成新的相并发生以前未观察到的相变。该计划的研究重点是设计可扩展的和溶液中合成方法，用于生产高产率的生物纳米颗粒组件，并涉及较少的合成和纯化步骤，同时保持高精度的纳米结构和可扩展的制造。具体来说，基于植物病毒的纳米颗粒将通过基因工程和植物中可扩展的分子农业来生产。球形和管状生物纳米粒子将以各种几何形状应用于基于溶液的化学和胶体合成。化学官能化将在原位进行，最大限度地减少限制产量的纯化程序。根据该奖项生产的方法和材料将为Janus基纳米颗粒及其更高有序结构的可扩展纳米制造提供新的途径。基于这些材料在医学、材料和能源领域的广泛适用性，设计有效的纳米制造方法预计将具有广泛的应用和对商业化的影响。例如，当用适当的配体或离子官能化时，所提出的Janus型材料在医疗保健、传感器、显示光学、能量转换和数据存储设备中具有可能的应用。这些材料和设备有助于提高生活质量、可持续性和技术竞争力。