Scalable Nanomanufacturing and Supra-Assembly of Virus-Hybrid Janus Bionanoparticles

这笔赠款提供资金，用于扩大纳米制造和组装基于病毒的Janus生物纳米颗粒，包括更高级别的结构。Janus一词指的是罗马掌管开始和过渡的神，用两张脸描绘。作为双面纳米物体，Janus型纳米材料与大多数传统的纳米粒子相比，提供了更高程度的功能和性能的可调性。它们还具有独特的自组装特性，可以形成新的相，并发生以前没有观察到的相变。该计划的研究重点是设计可扩展和溶液中的合成方法，以高产率生产这些生物纳米颗粒组件，并涉及较少的合成和纯化步骤，同时保持高精度的纳米结构和可扩展的制造。具体地说，将通过基因工程和可扩展的植物分子耕作来生产基于植物病毒的纳米颗粒。球形和管状生物纳米粒子将被应用于各种几何形状的溶液化学合成和胶体合成。化学功能化将在现场进行，最大限度地减少限制产量的提纯过程。根据该奖项生产的方法和材料将为基于Janus的纳米颗粒及其更高有序结构的可扩展纳米制造提供一条新的途径。基于这类材料在医学、材料和能源领域的广泛适用性，设计高效的纳米制造方法有望具有广泛的应用和对商业化的影响。例如，所提出的Janus型材料，当用适当的配体或离子功能化时，可能在医疗保健、传感器、显示光学、能量转换和数据存储设备中应用。这些材料和设备有助于提高生活质量、可持续性和技术竞争力。

This grant provides funding for scaled-up nanomanufacturing and assembly of virus-based Janus bio-nanoparticles including higher-order structures. The Janus term refers to the Roman god of beginnings and transitions, depicted with two faces. As dual-faced nano-objects, Janus-type nanomaterials offer a higher degree of functionality and tunability of properties compared to most traditional nanoparticles. They also have unique self-assembly properties, allowing new phases to form and phase transitions to occur that were not previously observed. Research under this program is focused on devising scalable and in-solution synthetic methods for the production of these bio-nanoparticle assemblies with high yields, and involving fewer synthetic and purification steps, while maintaining high-precision nanostructuring and scalable manufacturing. Specifically, plant virus-based nanoparticles will be produced through genetic engineering and scalable molecular farming in plants. Sphere- and tube-like bio-nanoparticles will be applied in various geometries for solution-based chemical and colloidal synthesis. Chemical functionalization will be carried out in situ, minimizing yield-limiting purification procedures. The methods and materials produced under this award will provide a new avenue towards scalable nanomanufacturing of Janus-based nanoparticles and their higher-ordered structures. Based on the broad applicability of such materials in areas of medicine, materials, and energy, devising methods for efficient nanomanufacturing is expected to have wide-ranging applications and impact on commercialization. For example, the proposed Janus-type materials, when functionalized with appropriate ligands or ions, have possible applications in healthcare, sensors, display optics, energy conversion, and data storage devices. These materials and devices can contribute towards enhanced quality of life, sustainability, and technological competitiveness.