MRI: Acquisition of an LC/MS/MS System for Multidisciplinary Research and Educational Projects

1338088化学液色谱(LC)被广泛应用于分析和生物分析领域，作为一种鉴定、定量和纯化混合物中存在的组分的常规技术。这方面的常规程序会给结果带来歧义。将质谱学纳入LC将有助于将这种不确定性降至最低。LC/MS/MS是一种具有很高灵敏度和选择性的强大技术。一般来说，它的应用面向在复杂混合物中存在其他化学物质的情况下对化学物质的具体检测和潜在识别，以涵盖从精确的质量测量和未知物的结构表征到痕量水平的定量分析的广泛应用。拉马尔大学(LU)正在努力提高他们在工程学院和文理学院环境和生化研究方面的分析能力。该小组正在申请资金，用于购买LC/MS/MS，用于教职员工和学生的研究项目以及大学间的合作项目。目前，陆上大学校园内没有LC/MS或LC/MS/MS仪器。研究人员必须在成本和准备时间极高的商业设施中进行这样的分析。如果能够获得LC/MS/MS，该团队计划实现以下两个目标：(I)基础研究和开发化学工程、土木和环境工程、化学和生物化学以及生物学的新分析方法，以及(Ii)应用最新技术和教学实践在这些领域教育学生。

1338088ChenLiquid Chromatography (LC) is widely used in analytical and bioanalytical areas as a routine technique to identify, quantify, and purify components present in a mixture. The conventional procedure for these imposes ambiguity on the results. Inclusion of Mass Spectroscopy to LC will help to minimize this uncertainty. LC/MS/MS is a powerful technique with very high sensitivity and selectivity. Generally its application is oriented towards the specific detection and potential identification of chemicals in the presence of other chemicals in a complex mixture to cover wide applications ranging from accurate mass measurement and structural characterization of unknowns to trace-level quantitative analysis. Lamar University (LU) is pursuing enhancement of their analytical capabilities for the environmental and biochemical research in both college of engineering and college of Arts & Science. The team is requesting funds for acquisition of a LC/MS/MS for faculty and student research projects and inter-university collaborative projects. Currently, there are no LC/MS or LC/MS/MS instruments on the LU campus. Researchers must get such analyses at commercial facilities where the costs and lead time are extremely high. If the LC/MS/MS can be acquired, the team plans to achieve the following two objectives: (i) basic research and development of new analysis methods in Chemical Engineering, Civil and Environmental Engineering, Chemistry and Biochemistry, and Biology, and (ii) application of the latest technology and pedagogical practices to educate students in these areas.