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Computational Electromechanics of the Heart: Development of FE-Based Predictive Simulation Tools for Patient Specific Analysis

心脏的计算机电学：开发基于有限元的预测模拟工具，用于患者特定分析

基本信息

批准号：
217579293
负责人：
Professor Dr.-Ing. Michael Kaliske
金额：
--
依托单位：
Institut für Statik und Dynamik der Tragwerke
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/217579293?language=en
关键词：
Computational Electromechanics Heart Development FE

项目摘要

Cardiovascular diseases caused 358,684 deaths in Germany 2007 and have an enormous epidemiological importance. They are also of extreme relevance from the health-economical view. The costs of cardiovascular diseases 2006 were nearly 35 billion Euro worldwide. Disturbed conduction and uncoordinated electrical signals can generate abnormal heart rhythms, so-called arrhythmias. Arrhythmias can cause a variety of symptoms from barely noticeable ones to cardiovascular collapse, cardiac arrest and death. Cardiologists can be supported during the patient-specific therapy through the development of efficient simulation tools for the systematic analysis of each clinical situation where the experimental techniques lack. The goal of the intended research is to establish novel and efficient numerical schemes for the electrophysiology and electromechanics of human heart and to carry out analysis of three-dimensional generic heart geometry in the first phase and a three-dimensional complex heart geometry based on MRI data and on local tissue anisotropy information in the second phase (2015-2017). The analysis of cardiac tissue is generally based on monodomain representation of myocardium where a homogenized response of extra- and intracellular medium is considered. However, this representation is too restrictive in modeling the (de)fibrillation phenomena, which necessitates bidomain representation. The bidomain model of cardiac tissue comprises a coupled system of equations describing the intracellular and extracellular potential fields. Particularly, efficient, fully implicit, bidomain based numerical tools and fully coupled electromechanical formulations will be developed. The resultant electrocardiograms (ECG) will be computed from bidomain based electrophysiological and fully electromechanical formulations.

2007年，心血管疾病在德国造成358,684人死亡，在流行病学方面具有巨大的重要性。从健康经济的角度来看，它们也极为相关。2006年全世界心血管疾病的费用接近350亿欧元。传导紊乱和不协调的电信号会产生异常的心律，即所谓的心律失常。心律失常可以引起各种各样的症状，从几乎不明显到心血管衰竭、心脏骤停和死亡。通过开发有效的模拟工具，系统分析实验技术所缺乏的每种临床情况，可以在患者特异性治疗期间为心脏病专家提供支持。本研究的目标是建立人类心脏电生理和电力学的新颖有效的数值方案，并在第一阶段进行三维一般心脏几何结构分析，在第二阶段进行基于MRI数据和局部组织各向异性信息的三维复杂心脏几何结构分析（2015-2017）。心脏组织的分析通常基于心肌的单域表示，其中考虑了细胞外和细胞内介质的均匀反应。然而，这种表示在模拟（去）纤颤现象时过于限制，这需要双域表示。心脏组织的双域模型包括一个描述细胞内和细胞外电位场的耦合方程组。特别是，高效的，完全隐式的，基于双域的数值工具和完全耦合的机电公式将被开发。由此产生的心电图（ECG）将从基于双域的电生理和全机电公式计算。