I-Corps: Single Chip Intravascular and Intracardiac Ultrasound Imaging Systems

I-Corps：单芯片血管内和心内超声成像系统

• 批准号: 1517521
• 负责人: Levent Degertekin
• 金额: $ 5万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1517521&HistoricalAwards=false
• 关键词: Corps; Single; Chip; Intravascular; Intracardiac

Coronary heart disease is one of the leading causes of death in the US and some 60M people in the US alone have some form of heart disease. Therefore, a great need exists for the advancement of devices and procedures to diagnose, treat, and correct a wide variety of forms of heart disease. Procedures such as radio frequency (RF) ablation to correct arrhythmias, reopening of totally blocked arteries and trans-catheter valve replacement are prolonged and sometimes not successfully performed due to the difficulties in the guidance of catheter based diagnostic and therapeutic devices within the cardiovascular system. This I-Corps team has developed a miniature forward looking 3-D ultrasound imaging system which essentially provides a flashlight for cardiologist or surgeons to navigate through the vascular system and within the heart. The proposed technology is developed to address the unmet need in image guidance for complex interventional heart procedures.The device that invented provides meaningful, real-time anatomical information occurring within the structures of the heart, as well as coronary and peripheral veins and arteries in a three dimensional view. The device should allow a less practiced clinician the ability to achieve the same results as a very skilled surgeon in less time and with similar accuracy. It should also allow certain catheter based minimally invasive procedures such as recanalization of blocked arteries which were declined because of the limitations of present devices, to now be done and avoid the open heart surgery. In the long term, the technology has the potential to displace the current catheter based ultrasound imaging systems completely by providing equal or better performance at reduced cost since it will dramatically reduce the assembly and catheter cabling which are the main cost drivers.

冠心病是美国的主要原因之一，仅美国就有约 6000 万人患有某种形式的心脏病。因此，非常需要改进设备和程序来诊断、治疗和纠正多种形式的心脏病。由于在心血管系统内基于导管的诊断和治疗设备的引导存在困难，诸如射频（RF）消融术以纠正心律失常、重新开放完全阻塞的动脉和经导管瓣膜置换术等手术时间较长，有时甚至无法成功实施。 I-Corps 团队开发了一种微型前视 3D 超声成像系统，该系统本质上为心脏病专家或外科医生提供了手电筒，以便在血管系统和心脏内导航。所提出的技术旨在解决复杂介入心脏手术中图像引导方面未满足的需求。发明的设备提供了心脏结构以及冠状动脉和外周静脉和动脉的三维视图中有意义的实时解剖信息。该设备应该允许经验较少的临床医生能够在更短的时间内以相似的精度获得与非常熟练的外科医生相同的结果。它还应该允许某些基于导管的微创手术，例如由于现有设备的限制而被拒绝的阻塞动脉再通术，现在可以进行并避免心脏直视手术。从长远来看，该技术有可能以更低的成本提供相同或更好的性能，从而完全取代当前基于导管的超声成像系统，因为它将大大减少主要成本驱动因素的组件和导管布线。