MRI: Acquisition of a 500 MHz NMR Spectrometer to Enhance Undergraduate Research at Wellesley College

MRI：购买 500 MHz NMR 波谱仪以加强韦尔斯利学院的本科生研究

• 批准号: 1528280
• 负责人: Megan Nunez
• 金额: $ 55.5万
• 依托单位: Wellesley College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1528280&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; NMR

This award from the Major Research Instrumentation Program (MRI) as well as additional support from the Chemistry Research Instrumentation (CRIF) and the Chemical Synthesis (SYN) Programs funds the acquisition of a 500 MHz NMR spectrometer by Wellesley College. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out modern research. This instrument is used in research on small organic molecules with potential anti-cancer and anti-tubercular properties, mutation of DNA oligonucleotides, and modified nanoparticles for imaging and medicinal usages. This spectrometer is also an integral component in training female undergraduate students. It is used by the students in courses and in their research projects. The proposal is aimed at enhancing research and education at all levels, especially in areas such as: (a) measuring equilibrium constants for base pair opening in DNA duplexes containing an abasic site lesion; (b) characterizing functionalization and magnetic properties of multipurpose nanoparticles; (c) determining the structure of novel coumarin derivatives with anti-tumor properties; (d) characterizing diverse pyrazolines as potential antitubercular agents; (e) synthesizing photoreactive small molecules to aid in the understanding of a GCPR transmembrane protein structure; and (f) using NOE methods to characterize the regiochemistry of N-substituted pyrazoles.

主要研究仪器计划（MRI）的这一奖项以及化学研究仪器（CRIF）和化学合成（SYN）计划的额外支持为韦尔斯利学院购买500 MHz NMR光谱仪提供了资金。核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事现代研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器用于研究具有潜在抗癌和抗结核特性的有机小分子、DNA寡核苷酸突变以及用于成像和医疗用途的改性纳米颗粒。该分光计也是培训女大学生的一个组成部分。它被学生用于课程和研究项目。该提案旨在加强各级研究和教育，特别是在以下领域：（a）测量含有无碱基位点损伤的DNA双链体中碱基对开放的平衡常数;（B）表征多用途纳米颗粒的功能化和磁性;（c）确定具有抗肿瘤特性的新型香豆素衍生物的结构;（d）表征作为潜在抗结核剂的不同吡唑啉;（e）合成光反应性小分子以帮助理解GCPR跨膜蛋白结构;和（f）使用NOE方法表征N-取代吡唑的区域化学。