MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance Undergraduate Research and Teaching at a Primarily Undergraduate Institution

该奖项由主要研究仪器项目和化学研究仪器项目支持。来自维拉诺瓦大学的凯文·明比奥教授和他的同事、来自梅西学院的罗伯特·朱利亚诺、迪安娜·祖布里斯、艾米·埃格勒和托马斯·乌迈勒·格温内德已经获得了一台500兆赫的核磁共振波谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究与生物相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该文书对几个参与宾夕法尼亚东南部高等教育联盟的机构产生了积极影响。课堂活动中有据可查的利用也是积极的。加入另一个机构(仁慈学院)的合作圆周率是对与其他机构合作的承诺的展示。授予核磁共振光谱仪旨在加强所有级别的研究和教育。它特别有助于鉴定天然产物的结构，以及快速和深入的两亲性结构表征，从而提高结构活性。该仪器还用于全面鉴定抗生素中的4-氨基糖和真菌毒素中的细胞表面多糖和糖基氰化物，以及确认双吡喃酮的结构。此外，它对于海绵衍生NRF2激活剂的合成类似物的表征以及在磷酸盐缓冲盐水中可氧化的二苯酚的结构变化的全面表征是必不可少的。该光谱仪可用于痕量天然产物的纯度测定和顺磁性铁络合物(催化剂)的表征，用于原子转移自由基聚合和机理评价。这一奖项反映了NSF的法定使命，通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Kevin Minbiole from Villanova University and colleagues Robert Giuliano, Deanna Zubris, Aimee Eggler and Thomas Umile Gwynedd from Mercy College have acquired a 500 MHz NMR spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts several institutions that participate in the Southeastern Pennsylvania Consortium for Higher Education. Well-documented utilization in classroom activities is also positive. Inclusion of a co-PI from another institution (Mercy College) is a demonstration of the commitment to partner with other institutions.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially aids in the identification of natural product structures and the rapid and in-depth structural characterization of amphiphiles that lead to improved structure-activity. The instrument is also used to fully characterize 4-amino sugars found in antibiotics and cell-surface glycans and glycosyl cyanides found in fungal toxins as well as in the confirmation of the structure of diplopyrone. In addition, it is essential for the characterization of synthetic analogues of marine sponge-derived Nrf2 activators and for the comprehensive characterization of structure changes in the oxidizable diphenols in phosphate buffered saline. The spectrometer benefits the determination of purity of trace amounts of purchased natural products and the characterization of paramagnetic iron complexes (catalysts) for atom transfer radical polymerization and mechanistic evaluation. It is also essential for the characterization of polymers containing multi-cationic quaternary ammonium compounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.