Endothelial damage caused by blood pressure measurement? Study on decrease in endothelium function following cuff occlusion and its application to diagnosis of atherosclerosis

血压测量会造成内皮损伤吗？

• 批准号: 24650295
• 负责人: MATSUMOTO Takeo
• 金额: $ 2.5万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650295/
• 关键词: バイオメカニクス; 動脈硬化; 血管内皮細胞; 血管平滑筋細胞; FMD

In ordinal blood pressure measurement, a cuff attached to the upper arm is first pressurized to stop blood flow in the brachial artery and then depressurized to observe the process of blood flow restoration. During this process, the brachial artery is occluded. To know the effects of the occlusion on the brachial artery, endothelial and smooth muscle functions were measured with the FMD method that is frequently used in clinical practice and a PMC method developed in our laboratory, respectively, before and after the occlusion.The results indicate that endothelial function but not smooth muscle function decreased following blood vessel occlusion, and recovery from this damage is faster in younger subjects. We also developed an animal model to reproduce this phenomenon.

在常规血压测量中，首先对连接到上臂的袖带加压以停止肱动脉中的血流，然后减压以观察血流恢复的过程。 在这个过程中，肱动脉被阻塞。 为了解闭塞对肱动脉的影响，分别用临床常用的FMD法和本实验室开发的PMC法测定闭塞前后的内皮功能和平滑肌功能，结果表明，血管闭塞后内皮功能下降，而平滑肌功能没有下降，并且年轻受试者从这种损伤中恢复得更快。 我们还开发了一种动物模型来重现这种现象。

项目成果

Development of a non-invasive multifaceted evaluation system for arterial function under transmural pressure manipulation

跨壁压力操作下动脉功能非侵入性多方面评估系统的开发

• 发表时间: 2013
• 作者: Yaguchi T;Nagayama K;Tsukahara H;Masuda H;Matsumoto T
• 通讯作者: Matsumoto T

Heterogeneity of deformation of aortic wall at the microscopic level: Contribution of heterogeneous distribution of collagen fibers in the wall

• DOI: 10.3233/bme-130771
• 发表时间: 2013-01-01
• 期刊: BIO-MEDICAL MATERIALS AND ENGINEERING
• 影响因子: 1
• 作者: Sugita, Shukei;Matsumoto, Takeo
• 通讯作者: Matsumoto, Takeo

血管壁のバイオメカニクス

血管壁的生物力学

• 发表时间: 2012
• 作者: Pham TT;Nishijo M;Nakagawa H;Maruzeni S;Nguyen TNA;Hoang VL;Tran HA;Nguyen DB;Morikawa Y;Kido T;Nishijo H.;松本 健郎
• 通讯作者: 松本 健郎

Measurement of Circumferential Strain Distribution in Human Coronary Arteries with Atherosclerotic Plaque

动脉粥样硬化斑块测量人体冠状动脉周向应变分布

• DOI: 10.1299/kikaia.79.177
• 发表时间: 2013
• 期刊: TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A
• 作者: 杉田修啓;松本健郎;増田弘毅;佐藤正明
• 通讯作者: 佐藤正明

ヒト腕動脈内圧−径関係の非侵襲的計測の試み

无创测量人体肱动脉内压-直径关系的尝试

• 发表时间: 2012
• 作者: Matsumoto T;Uno Y;Nagayama K;矢口俊之,武澤健司,長山和亮,益田博之,松本健郎
• 通讯作者: 矢口俊之,武澤健司,長山和亮,益田博之,松本健郎