Endothelial damage caused by blood pressure measurement? Study on decrease in endothelium function following cuff occlusion and its application to diagnosis of atherosclerosis

在常规血压测量中，首先对上臂上的袖带加压，阻断肱动脉血流，然后再降压，观察血流恢复过程。在此过程中，肱动脉被阻塞。为了了解闭塞对肱动脉的影响，分别用临床常用的FMD法和我们实验室开发的PMC法测量闭塞前后的内皮肌和平滑肌功能。结果表明，血管闭塞后，内皮功能而非平滑肌功能下降，并且年轻受试者从这种损伤中恢复得更快。我们还开发了一个动物模型来重现这一现象。

In ordinal blood pressure measurement, a cuff attached to the upper arm is first pressurized to stop blood flow in the brachial artery and then depressurized to observe the process of blood flow restoration. During this process, the brachial artery is occluded. To know the effects of the occlusion on the brachial artery, endothelial and smooth muscle functions were measured with the FMD method that is frequently used in clinical practice and a PMC method developed in our laboratory, respectively, before and after the occlusion.The results indicate that endothelial function but not smooth muscle function decreased following blood vessel occlusion, and recovery from this damage is faster in younger subjects. We also developed an animal model to reproduce this phenomenon.