Neuroendocrinological Studies of Fish Puberty

鱼类青春期的神经内分泌学研究

• 批准号: 23658163
• 负责人: MATSUYAMA Michiya
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658163/
• 关键词: 春季発動; キスペプチン; 神経ペプチド; 春機発動; Kiss; GnRH; GtH; マサバ

Kisspeptins, encoded by kissgenes have emerged as critical regulator of reproductive function in vertebrates. In the present study, we evaluated the potency of Kiss1 and Kiss2 to induce pubertal onset in prepubertal chub mackerel. Gonadosomatic index (GSI) of Kiss1 treated fish increased significantly in comparison to other treatments. Histologically, 66.7% of Kiss1 treated fish exhibited presence of spermatozoa in the testes. However,Kiss2-12 treated fish showed only spermatocytes as the advanced germ cells in the testes. In contrast, only spermatogonia were observed in the testes of initial and untreated final control fish. Levels of sex steroids were significantly higher in Kiss1 treated fish. These results indicate application of Kiss1 peptides for accelerating pubertal onset in chub mackerel.

kisspeptins是由kissgenes编码的一种蛋白质，在脊椎动物中起着重要的生殖调节作用.在本研究中，我们评估的效力Kiss 1和Kiss 2诱导青春期开始在青春期前的鲭鱼。与其他处理相比，Kiss 1处理的鱼的性腺指数（GSI）显着增加。在组织学上，66.7%的Kiss 1处理的鱼表现出精子在睾丸中的存在。然而，Kiss 2 -12处理的鱼仅显示精母细胞作为睾丸中的高级生殖细胞。相比之下，在初始和未处理的最终对照鱼的睾丸中仅观察到精原细胞。性类固醇的水平显着较高的Kiss 1处理的鱼。这些结果表明Kiss 1肽用于加速鲭鱼青春期的开始。

项目成果

Kiss1 pentadecapeptide induces spermatogenesis in prepbertal male chub mackerel, Scomber japonicus

Kiss1 十五肽诱导产前雄性鲭鱼、鲭鱼的精子发生

• 发表时间: 2013
• 作者: M Nyuji;et al;入路光雄，松山倫也;Adachi H;Ohga H;Selvaraj S.
• 通讯作者: Selvaraj S.

KISS1 PENTADECAPEPTIDE INDUCES SPERMATOGENESIS IN PREPUBERTAL MALE CHUB MACKEREL (Scomber japonicus)

KISS1 十五肽诱导青春期前雄性鲭鱼（鲭鱼）的精子发生

• 发表时间: 2013
• 作者: M Nyuji;et al;入路光雄，松山倫也;Adachi H;Ohga H;Selvaraj S.;入路光雄;Adachi H;Ohga M;Selvaraj S
• 通讯作者: Selvaraj S

Temporal expressions of Kisspeptins, Kispeptin receptors, GnRHs and GtHs during the prepubertal process of chub mackerel, Scomber japonicus

鲭鱼青春期前Kisspeptins、Kispeptin受体、GnRHs和GtHs的时间表达

• 发表时间: 2013
• 作者: M Nyuji;et al;入路光雄，松山倫也;Adachi H
• 通讯作者: Adachi H

TEMPORAL EXPRESSIONS OF KISSPEPTINS, KISSPEPTIN RECEPTORS, GNRHS AND GTHS DURING THE PUBERTAL PROCESS OF CHUB MACKEREL, Scomber japonicus

鲭鱼青春期过程中 KISSPEPTIN、KISSPEPTIN 受体、GNRHS 和 GTHS 的时间表达

• 发表时间: 2013
• 作者: M Nyuji;et al;入路光雄，松山倫也;Adachi H;Ohga H;Selvaraj S.;入路光雄;Adachi H
• 通讯作者: Adachi H

Steroidogenic and maturation-inducing potency of native gonadotropic hormones in female chub mackerel, Scomber japonicus.

• DOI: 10.1186/1477-7827-10-71
• 发表时间: 2012-09-05
• 期刊: Reproductive biology and endocrinology : RB&E
• 作者: Ohga H;Kaneko K;Shimizu A;Kitano H;Selvaraj S;Nyuji M;Adachi H;Yamaguchi A;Matsuyama M
• 通讯作者: Matsuyama M