Study of activated carbon adsorbing anticancer drugs for chemotherapy of lymphnode metastasis and peritoneal metastasis.

本项目研制了新型药物剂型“活性碳吸附抗癌药物”。活性碳具有大量的微球，具有很大的比表面积，可以吸附或解吸表面的药物。当它被注射到组织中时，它被吸附到毛细淋巴管中，并立即到达区域淋巴结。当它被注射到癌性胸膜或腹膜腔内时，它会被吸附在癌症和浆膜表面。利用这些性质，我们制备了吸附丝裂霉素C(MMC-CH)或阿霉素(ADM-CH)的活性碳，用于淋巴转移和腹膜转移的化疗。动物实验表明，吸附MMC或ADM的活性碳对淋巴结转移和胸膜、腹膜转移有很好的疗效。MMC-CH和ADM-CH用于治疗胃癌、乳腺癌和结肠癌的淋巴结转移。除了淋巴结转移的化疗外，用活性碳染成黑色的淋巴结容易被外科医生识别，许多淋巴结被清扫。73例癌性腹膜炎患者中有45例对MMC-CH有反应。结果表明，吸附抗癌药物的活性碳对淋巴转移和胸膜、腹膜转移的化疗有较好的疗效。

In this project new drug dosage form "activated carbon adsorbing anticancer drug" was produced. Activated carbon has numerous microposes that possesses great surface area and can adsorb or desorb the drug on the surface. When it is injected into tissues, it is adsorbed into the lymphatic capillaries and immediately reaches the regional lymph nodes. When it is injected into a cancerous pleural or abdominal cavity, it is adsorbed on cancer and serosal surface. Using these properties of the activated carbon, we have prepared activated carbon adsorbing Mitomycin C (MMC-CH) or Adriamicin (ADM-CH) for chemotherapy of lymphnodes metastasis and peritoneal metastasis. Animal experiments revealed that activated carbon adsorbing MMC or ADM was very effective on lymphnode metastasis and pleural or peritoneal metastasis.MMC-CH and ADM-CH were applied to the patients with carcinoma of the stomach, breast and colon for the treatment of lymphnode metastasis. Beside the chemotherapy of lymphnode metastasis, lymphnodes stained in black by activated carbon were easily identified by surgeons,and many lymphnodes were dissected.Forty five of 73 patients with carcinomatous peritonitis responded to MMC-CH. No serious adverse effect was observed.As a result, activated carbon adsorbing anticancer drug was very useful for chemotherapy of lymphnode metastasis and pleural or peritoneal metastasis.