Study of activated carbon adsorbing anticancer drugs for chemotherapy of lymphnode metastasis and peritoneal metastasis.

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In this project new drug dosage form "activated carbon adsorbing anticancer drug" was produced. Activated carbon has numerous microposes that possesses great surface area and can adsorb or desorb the drug on the surface. When it is injected into tissues, it is adsorbed into the lymphatic capillaries and immediately reaches the regional lymph nodes. When it is injected into a cancerous pleural or abdominal cavity, it is adsorbed on cancer and serosal surface. Using these properties of the activated carbon, we have prepared activated carbon adsorbing Mitomycin C (MMC-CH) or Adriamicin (ADM-CH) for chemotherapy of lymphnodes metastasis and peritoneal metastasis. Animal experiments revealed that activated carbon adsorbing MMC or ADM was very effective on lymphnode metastasis and pleural or peritoneal metastasis.MMC-CH and ADM-CH were applied to the patients with carcinoma of the stomach, breast and colon for the treatment of lymphnode metastasis. Beside the chemotherapy of lymphnode metastasis, lymphnodes stained in black by activated carbon were easily identified by surgeons,and many lymphnodes were dissected.Forty five of 73 patients with carcinomatous peritonitis responded to MMC-CH. No serious adverse effect was observed.As a result, activated carbon adsorbing anticancer drug was very useful for chemotherapy of lymphnode metastasis and pleural or peritoneal metastasis.