DEVELOPMENT OF MONOCLONAL ANTIBODY-GUIDED SURGERY FOR CANCER PATIENTS.
DEVELOPMENT OF MONOCLONAL ANTIBODY-GUIDED SURGERY FOR CANCER PATIENTS.
批准号:
05454373
负责人:
TAKAHASHI Toshio
金额:
$3.39万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994
中文摘要
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英文摘要
MONOCLONAL ANTIBODY WAS LABELED WITH ^<131>I OR ^<111>In. THE SENSITIVITY OF ^<111>In WAS BETTER THAN THAT OF ^<131>I,THOUGH NON SPECIFIC ACCUMULATION OF LABELED ANTIBODY WAS HIGHER IN ^<111>In LABELED ANTIBODY.METASTATIC LESION OF COLON CANCER WAS DETECTED BY INTRAOPERATIVE SURVEY USING MINI-PROBE FOR GAMMA-RAY DETECTION.BUT THE SENSITIVITY WAS NOT SATISFACTORY IN CASE OF SMALL METASTASIS.HISTOLOGICAL AUTORADIOGRAPHY SHOWED SELECTIVE ACCUMULATION OF LABELED ANTIBODY TO CANCER TISSUE AND NON-SPECIFIC DISTRIBUTION TO NORMAL MUCOSA WAS MINIMUM.CLINICAL DATA SHOWED THAT 5mCi OF LABELED ANTIBODY WAS ENOUGH TO DETECT METASTATIC LE-SION.AND SCANNING AT 48 HOURS AFTER ADMINISTRATION OF LABELED ANTIBODY SHOWED BEST IMAGE OF CANCER LESION.RADIOIMMUNOGUIDED SURGERY WAS USUEFUL INCASE OF DECIDING THE LIMIT OF EXCISION TUMOR.FROM THESE RESULTS,IMMUNO-GUIDED SURGERY USING RADIOLABELED MONOCLONAL ANTIBODY SEEMED TO BE PROMISING METHOD FOR CANCER SURGERY.
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Yamaguchi, T.et al: "In vivo efficacy of neocarzinostatin coupled with Fab human/chimeric monoclonal antibody A7 against colorectal cancer." Jpn.J.Cancer Res.85. 167-171 (1994)
Yamaguchi, T.等人:“新制癌菌素与 Fab 人/嵌合单克隆抗体 A7 结合对抗结直肠癌的体内功效。”
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通讯作者:
Kitamura,K.: "The role of monoclonal antibody A7 as a drug modifier in cancer therapy." Cancer Immunol.Immunother. 36. 177-184 (1993)
Kitamura,K.:“单克隆抗体 A7 作为药物修饰剂在癌症治疗中的作用。”
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T.Yamaguchi: "In vivo efficacy of neocarzinostatin coupled with Fab human/mouse chimeric monoclonal antibody A7 against human colorectal cancer." Jpn.J.Cancer Res.85. 167-171 (1994)
T.Yamaguchi:“新制癌菌素与 Fab 人/小鼠嵌合单克隆抗体 A7 结合对抗人结直肠癌的体内功效。”
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通讯作者:
高橋俊雄: "モノクローナル抗体のDDSへの応用." カレントテラピー. 12. 166-174 (1994)
Toshio Takahashi:“单克隆抗体在 DDS 中的应用。”当前疗法。12. 166-174 (1994)
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Takahashi,T.: "Followup study of patients treated with monoclonal antibody-drug conjugate;Report of 77 cases with colo-rectal cancer." Jpn.J.Cancer Res.84. 976-981 (1993)
Takahashi,T.:“用单克隆抗体-药物偶联物治疗的患者的随访研究;77 例结直肠癌病例的报告。”
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共 21 条
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Immunotargeting Chemotherapy of Gastrointestinal Carcinoma using Monoclonal Antibody-Drug Conjugates
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